Serum Calcium and Electrolytes in Hypothyroidism - A Case Control Study
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 3
Abstract
Introduction: Hypothyroidism is the most common form of endocrine abnormality resulting from the deficiency of thyroid hormones or from their impaired activity. Different electrolyte disorders in association with thyroid dysfunction were observed in the literature. The effect of thyroid hormones on minerals has not been well established and the underlying mechanism is not well understood too. So, the present study was undertaken to assess the alterations in the levels of serum calcium, sodium, potassium and chlorides and to correlate these minerals with TSH in hypothyroidism. Materials and methods: A case control study is taken up on 40 subjects with hypothyroidism and 40 apparently normal healthy subjects. Venous blood sample is collected from all the subjects. Serum TSH, calcium, sodium, potassium and chlorides are estimated in all the subjects. Results: A significant decrease in serum calcium, sodium and potassium is observed in cases in comparison to controls (p<0.0001). A significant increase in serum chlorides is observed in cases (p=0.03) compared to controls. When correlated with TSH, serum calcium, sodium, potassium and chlorides showed negative correlation in subjects with hypothyroidism. Conclusion: The present study indicates the profound influence of thyroid hormones on serum electrolytes. This study concludes that serum calcium, sodium and potassium levels are decreased whereas serum chloride levels are increased in hypothyroidism in comparison to euthyroid subjects. We suggest that hypothyroid patients should be regularly monitored for serum electrolytes. Monitoring of these parameters in hypothyroidism will be of great help in its management.
Authors and Affiliations
Amrut A Dambal, D. Sridevi, Sidrah . , Samata K Padaki
Keywords
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