SERUM CALCIUM, PHOSPHORUS, MAGNESIUM AND ALBUMIN LEVELS IN PATIENTS WITH CHRONIC RENAL FAILURE IN SENNAR HOSPITAL FOR RENAL DISEASES, SENNAR STATE, SUDAN, AUGUST 2018
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 9
Abstract
Background: Chronic kidney disease (CKD) is an irreversible loss of renal function for at least three months. It is accompanied by profound changes in calcium, phosphorus, magnesium and albumin metabolism. These alterations contribute to serious complications such as cardiovascular disease and bone disease. Objective: This study aim to evaluate serum calcium, phosphorus, magnesium and albumin levels in patients with chronic renal failure. Materials and Methods: The study includes 120 samples, 80 blood samples were taken from patients with chronic renal failure in Sennar hospital for renal diseases included 44 males (55%) and 36 females (45%), the average age of the patients was 44.26 ± 19.10 years, and 40 apparently healthy individuals (control group) included 18 males (45%) and 22 females (55%) the average age of control group was 37.1 ± 18.3 years. Calcium, phosphorus, magnesium and albumin levels were measured by using chemistry analyzer A15. Statistical tests were used to assess difference in the mean of studied concentrations between cases and the control group. Result: The results showed that calcium and albumin concentrations were significantly lower in the patients (M±SD = 8.63 ± 1.37, M±SD = 3.39 ± 0.82) compared with controls (M±SD = 9.13 ± 0.463, M±SD = 3.8 ± 0.41, P = 0.000, P = 0.001). Phosphorus and magnesium concentrations were significantly higher in the patients (M±SD = 3.9 ± 2.07, M±SD = 2.69 ± 0.85) compared with control group (M±SD = 3.13 ± 0.40, M±SD = 1.93 ± 0.27, P = 0.000, P = 0.000), respectively. Conclusion: In this study hypocalcaemia was reported in 46% of the patients, hyperphosphatemia was found in 29% of the patients, and hypermagnesemia and hypoalbuminemia were found in more than half of the patients (66%, 61%, respectively). More studies must be done to confirm these results and screening programs should be done to reduce the burden and to prevent the complications of chronic kidney disease.
Authors and Affiliations
Dr. Yasir Hakim
Keywords
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