Serum cholesterol is a significant and independent mortality predictor in liver cirrhosis patients
Journal Title: Annals of Hepatology - Year 2013, Vol 12, Issue 4
Abstract
Background and Aim. Accurate assessment of cirrhotic patient’s prognosis is essential for decisions regarding the course of treatment. Therefore we aimed to confirm and quantify the predictive value of serum cholesterol and serum triglycerides in liver cirrhosis patients. Material and methods. We performed a retrospective observational cohort study on consecutive patients with liver cirrhosis (n = 191). Relevant clinical and laboratory variables were obtained from patients‘ charts and patients were followed for two months. Mortality was the main outcome. Results. Thirty-eight patients died in the follow-up period. Significant difference was observed in the level of total serum cholesterol between surviving and deceased patients (2.27 ± 1.02 mmol/L vs. 2.97 ± 1.00 mmol/L, P < 0.0001 respectively). Cholesterol was confirmed as a significant predictor of mortality in univariate logistic regression analysis, and independent predictor beside bilirubin, creatinine and MELD score in multivariate logistic regression analysis. Addition of serum cholesterol level to a prognostic model based on total bilirubin, creatinine and INR increased its accuracy by 4%. Adding cholesterol to the MELD score improved prediction accuracy by 3%. There was no significant difference in serum levels of triglycerides between surviving and deceased patients. Conclusion. Serum cholesterol is a routinely measured parameter, which has independent prognostic value in patients with liver cirrhosis.
Authors and Affiliations
Martin Janicko, Eduard Veselíny, Dušan Leško, Peter Jarcuška
Keywords
Related Articles
- EP ID EP78302
- DOI -
- Views 106
- Downloads 0
Minimal hepatic encephalopathy. Should we treat it?
A 25 years old women after Kasai operation for biliary atresia
Percutaneous liver biopsy – 2 decades of experience in a public hospital in the South of Brazil
Introduction. Liver biopsy is a complementary method for diagnosis, staging and therapeutic guidance in liver diseases, where chronic viral hepatitis are the most acknowledged causes for the indication of histopathologic...
Early allograft dysfunction after liver transplantation: an intermediate outcome measure for targeted improvements
Background. The term early allograft dysfunction (EAD) identifies liver transplant (LT) allografts with initial poor function and portends poor allograft and patient survival. Aims of this study are to use EAD as an inte...
The effect of bacterial infections in cirrhotic patients with esophageal variceal bleeding
Background. Cirrhotic patients are prone to having bacterial infections due to impaired innate immunity. This nationwide population-based study aimed to identify the effect of bacterial infections on the mortality of the...