SERUM CORTISOL LEVEL IN LUNG CANCER PATIENTS AT VARIOUS STAGES OF DIAGNOSIS
Journal Title: International Journal of Basic and Applied Physiology - Year 2014, Vol 3, Issue 1
Abstract
Background & Objectives: Lung cancer is the leading cause of death in developed countries and is rising in alarming rates in developing countries. Diagnosis of lung cancer is a form of psychological stress, so there may be neuroendocrine alteration in these patients like elevated serum cortisol level, as cortisol is considered as ‘stress hormone’. The study was designed to compare the serum cortisol levels in lung cancer patients at various stages of diagnosis. Methods: The study was conducted in 3 sub groups of lung cancer patients (n=150) and controls (n=150) in Upgraded Department of Physiology, S.M.S.Medical College, Jaipur to estimate serum cortisol level by ELISA (Enzyme Linked Immuno Sorbent Assay) method. Results: The mean serum cortisol levels were highest in sub group A (676.82 nmol/l) followed by sub group B (557.27 nmol/l) and sub group C (236.61 nmol/l). These differences were found highly significant on application of ANOVA (p<0.0001). Interpretation & Conclusion: The level of serum cortisol was highest in newly diagnosed lung cancer patients. The data obtained also indicate that the high cortisol level is due to more psychological disturbances in newly diagnosed patients.
Authors and Affiliations
Preeti Sharma, Keerti Mathur, Rakesh Sharma, Manisha Sankhla
Keywords
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- EP ID EP546806
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