Serum Ferritin: An Early Marker of Insulin Resistance in Metabolic Syndrome
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 2
Abstract
Background: Metabolic syndrome (MetS) is a combination of conditions that include hyperinsulinemia, obesity, dyslipidemia, and hypertension. Increased body iron stores are associated with the development of glucose intolerance, type 2 diabetes mellitus, and insulin resistance (IR) syndrome. Ferritin, being an acute phase reactant, has a tendency to increase in inflammatory conditions. Although the etiopathogenesis of MetS have been linked to iron overload and IR, controversy exists about the levels of ferritin in MetS. Hence, we aimed to estimate the levels of ferritin in cases of MetS and to correlate their levels with the individual components of MetS. Materials and Methods: This Case–control study included a total of 140 participants with 70 cases and 70 controls. Cases were selected on the basis of modified the National Cholesterol Education Program Adult Treatment Panel III Criteria. Their fasting blood samples were collected to estimate blood sugar, iron, ferritin, and insulin. IR was calculated using homeostasis model assessment IR (HOMA-IR) formula. Statistical analysis was performed by independent t-test, Mann–Whitney U-test, Pearson’s correlation test, and Spearman’s correlation test. Results: Serum ferritin, iron, insulin, and HOMA-IR were significantly high (P < 0.001) in cases when compared to controls. We found a significant positive correlation between iron levels and HOMA-IR ([r = 0.846, P < 0.001] and [r = 0.432, P = 0.010]) in males and females, respectively. Similarly, we found a significant positive correlation between ferritin levels and HOMA-IR ([r = 0.705, P < 0.001] and [r = 0.509, P = 0.002]) in males and females respectively. Conclusion: Serum ferritin plays a key role in the pathogenesis of MetS and could be used as a marker for early diagnosis of MetS.
Authors and Affiliations
J Sivasankari, V Thiruchelvan
Keywords
Related Articles
- EP ID EP466541
- DOI -
- Views 106
- Downloads 0
Efficacy of Ropivacaine in Wound Instillation through Surgical Drains for Post-operative Analgesia in Modified Radical Mastectomy
Background: “Pain” is an unpleasant sensory and emotional experience associated with actual or potential tissue damage after any surgery so as in breast surgery. Successful pain management should be a central component o...
Characterization of Focal Liver Lesions Using SonoVue, Contrast-enhanced Ultrasound
Introduction: Focal liver lesions are frequently discovered in daily practice owing to extensive use of imaging methods. Their nature must be elucidated for prognosis assessment and to decide on therapeutic strategy. Aim...
Clinical Study of Visual Outcome and Intraocular Pressure Changes Following Neodymium-doped Yttrium Aluminum Garnet Laser Capsulotomy in Post-operative Cataract Patients with Posterior Capsule Opacification
Background: The use of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser procedure for posterior capsulotomy has been gradually replacing the surgical capsulotomy as it is less invasive, and can be performed as an o...
Clinico-pathological Study of Pancytopenia: A Prospective Study
Background and Objectives: Pancytopenia is an important hematological entity. It is a disorder in which all three major formed elements of blood are decreased in number. The present study has been undertaken to find out...
Role of Cartridge-based Nucleic Acid Amplification Test in Diagnosis of Tuberculous Pleural Effusion Compared to Tuberculous Empyema in HIV-seronegative Patients
Introduction: The tuberculous pleural effusion is the second most common form of extrapulmonary tuberculosis (TB) in high TB burden country such as India. Since the endorsement of cartridge-based nucleic acid amplificati...