Serum ferritin level in type 2 diabetes mellitus - A case control study
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 1
Abstract
Background: Hyperferritinemia probably contributes insulin resistance and subsequently to decreased insulin secretion causes for development of insulin resistance. Objectives: Compare HbA1c with Ferritin and find correlation between HbA1c and ferritin in type 2 diabetes mellitus patients, and also to find the best cut-off value for serum ferritin. Material and methods: The study was conducted on type 2 diabetes mellitus patients attended the outpatient department. Totally 99 participants were enrolled for the study, out of which 49 were cases and 50 were age and sex controls. The FBS, PPBS, HbA1c and serum ferritin were estimated. Statistical package for social science software version 19.0 was used for statistical analysis. Results: There statistically significant increase in all the biochemical parameters viz FBS, PPBS, HbA1c and serum ferritin levels in cases compared controls. The p value was 0.0001 for all the parameters, which is highly significant. There was a positive correlation between the HbA1c and Ferritin levels, but it was not statistically significant (r = 0.10). The area under the ROC curve for serum ferritin values at various cut-off was 0.904 and the best cut-off of serum ferritin levels greater than 124ng/ml. Conclusion: Serum ferritin levels were higher in type 2 Diabetes mellitus which positively correlated HbA1c. Thus, routine screening for serum ferritin concentration in diabetes patients can be done to assess the glecemic control in type 2 DM
Authors and Affiliations
Sangappa Virupaxappa Kashinakunti, Kavitha Hiremath, Manjula Rangappa, Gurupadappa Shantappa Kallaganada
Keywords
Related Articles
- EP ID EP242130
- DOI -
- Views 111
- Downloads 0
Estimation of prostate specific antigen in metabolic syndrome- a study in south Indian male population
Introduction: The main aim of our study was to assess the role of prostate specific antigen in Indian males and to determine its correlation with insulin resistance in metabolic syndrome. Materials and Methods: For this...
Frequency of ABO blood group and Rhesus factor (D) in patients of type 2 diabetes mellitus attending tertiary care teaching hospital of South India
Introduction and Objective Diabetes mellitus DM is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion insulin action or both After discovery of ABO human blood group...
Study of free radicals (malondialdehyde) in pre-eclampsia and eclampsia in correlation with uric acid and total proteins
Introduction Oxidative stress is a normal phenomenon in normotensive pregnancy however in preeclampsia oxidative stress is exaggerated may result in a greater potential for endothelial oxidative damage It has been report...
A study to evaluate the vitamin D status in rheumatoid arthritis patients
Introduction: Vitamin D deficiency has been shown to be associated with autoimmune diseases, which is a controversial finding in various previous studies. Moreover there are limited studies done on serum vitamin D and it...
Studies on serum soluble endoglin: An indicator for preeclampsia
Introduction To study the concentration of serum soluble endoglin during second trimester pregnancy and monitor for the development of preeclampsiaMaterials and Methods Seventyfive healthy singleton pregnant women in sec...