SERUM FETUIN -A LEVELS IN NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS PATIENTS
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 12
Abstract
Introduction: Serum fetuin-A is a multifunctional circulating glycoprotein which inhibits the insulin receptor tyrosine kinase activity and induces a low grade inflammation which results in insulin resistance. High levels of fetuin-A are associated with insulin resistance. Materials & Methods: The present study included 100 cases and 100 age matched healthy controls, visiting medical outpatient department of SGT Medical College and Hospital, Haryana. Results: The mean FPG, PPBG, TC, TG, VLDL, LDL, HbA1c and serum fetuin-A levels were significantly higher in diabetic group compared to controls. Serum fetuin-A is positively correlated with FBG, HbA1c, TG, TC, and VLDL and negatively correlated with HDL in diabetic patients as compared to healthy controls. Conclusion: This study concluded that serum fetuin-A is significantly elevated in T2DM patients and it indicates that serum fetuin -A may play a role in pathogenesis of diabetes by inhibiting insulin receptor tyrosine kinase and insulin signalling.
Authors and Affiliations
Dr. Dharambir, Dr Poonam Arora, Dr. Busi Karunanand
Keywords
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