Serum gamma-glutamyltransferase (γ-GT) and cardiovascular disease
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2008, Vol 25, Issue 6
Abstract
Following the introduction of serum γ-GT in clinical practice as a reliable, routinely employed laboratory test, epidemiological and prospective studies have repeatedly shown that this activity has prognostic value for morbidity and mortality. Notably, a significant independent correlation of serum γ-GT is observed with cardiovascular disease (myocardial infarction, stroke, diabetes mellitus, and metabolic syndrome) and this association is independent of concomitant liver disease. Experimental studies have documented the presence of active γ-GT in atherosclerotic plaques in the coronary and cerebral arteries. These findings and the recently recognized functions of γ-GT in the generation of reactive oxygen species indicate that serum γ-GT represents a true marker of cardiovascular disease and underlying atherosclerosis.
Authors and Affiliations
N. VALLIANOU, P. KOUTALAS
Keywords
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