Serum Homocysteine Levels As a Novel Biomarker in Patients with Acute Myocardial Infarction
Journal Title: International Journal of Medical and Health Sciences - Year 2012, Vol 1, Issue 4
Abstract
Background:Cardiovascular diseases are the number one cause of mortality worldwide. 15-20% of major cardiovascular events occur in patients with no major traditional cardiovascular risk factors. As a result efforts have been directed at finding newer & better biomarkers which can predict about such cases. Materials & Methods:In this study, 50 patients diagnosed with acute myocardial infarction were studied for serum homocystine levels & compared with age and sex matched 50 controls selected by simple random sampling. Fasting plasma Homocysteine level was estimatied using Enzymatic photometry. Results:Results obtained indicated that risk of myocardial infarction increases with age and is seen predominantly in males. The serum homocysteine levels of the study group (22.85±8.61 mol/l) was significantly higher than the control group(13.84±7.03 mol/l). The serum homocysteine levels in those who expired were higher in those who expired (25.21± mol/l) than in those who survived (22.48±8.82micromol/l) at one year however this finding was not statistically significant. All these observations correlated well with the observations made by other studies conducted by various authors. Conclusion:Homocystein is a novel biomarker in patients with acute myocardial infarction. Homocysteine levels in myocardial infarction patient are important and useful biomarker to predict long term mortality risk.
Authors and Affiliations
Vinod Wali, Singi Yatiraj, Kiran Deshmukh,Nagaraj Bijapur
Keywords
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