Serum Level of Heart-Type Fatty Acid-Binding Protein in Patients with Chronic Renal Failure
Journal Title: Sultan Qaboos University Medical Journal - Year 2009, Vol 9, Issue 3
Abstract
Heart-type fatty acid binding-protein (H-FABP) has been reported to be a potential novel biochemical marker for the early diagnosis of acute myocardial infarction (AMI). Te effect of kidney diseases on the renal handling of H-FABP has not yet been fully evaluated. Te aim of this study was to compare the effect of renal failure on the level of H-FABP and cardiac troponin (cTnT) concentrations. Methods: Te study population was a small group of 16 patients with renal failure (6 females, 10 males aged 30-70 years) on routine regular haemodialysis or peritoneal dialysis. Results: Te mean ±SD of serum urea and creatinine concentration in this group of patients was 19 ±9.6 mmol/L and 531.3 ±231.2 mmol/L respectively. H-FABP was increased in all 16 patients (81 ±53.3µg/L). Te cTnT was increased ≥ 0.1µg/L in 8 patients (50%), ≥ 0.2µg/L in 5 patients (31.3%), and ≥ 0.3µg/L in 1 patient (6%). Conclusion: Te diagnostic efciency of H-FABP and cTnT for the diagnosis of AMI in the presence of renal failure may be limited and such patients may have high levels even in the absence of AMI.
Authors and Affiliations
Hafdh A Al-Hadi| Department of Medicine, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, Brent William| Department of Medical Sciences, Faculty of Medicine, Edinburgh University, UK, Keith A Fox| University of Edinburgh, Cardiovascular Research Unit, Royal Infrmary of Edinburgh, UK
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