Serum Level of Heart-Type Fatty Acid-Binding Protein in Patients with Chronic Renal Failure
Journal Title: Sultan Qaboos University Medical Journal - Year 2009, Vol 9, Issue 3
Abstract
Heart-type fatty acid binding-protein (H-FABP) has been reported to be a potential novel biochemical marker for the early diagnosis of acute myocardial infarction (AMI). Te effect of kidney diseases on the renal handling of H-FABP has not yet been fully evaluated. Te aim of this study was to compare the effect of renal failure on the level of H-FABP and cardiac troponin (cTnT) concentrations. Methods: Te study population was a small group of 16 patients with renal failure (6 females, 10 males aged 30-70 years) on routine regular haemodialysis or peritoneal dialysis. Results: Te mean ±SD of serum urea and creatinine concentration in this group of patients was 19 ±9.6 mmol/L and 531.3 ±231.2 mmol/L respectively. H-FABP was increased in all 16 patients (81 ±53.3µg/L). Te cTnT was increased ≥ 0.1µg/L in 8 patients (50%), ≥ 0.2µg/L in 5 patients (31.3%), and ≥ 0.3µg/L in 1 patient (6%). Conclusion: Te diagnostic efciency of H-FABP and cTnT for the diagnosis of AMI in the presence of renal failure may be limited and such patients may have high levels even in the absence of AMI.
Authors and Affiliations
Hafdh A Al-Hadi| Department of Medicine, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, Brent William| Department of Medical Sciences, Faculty of Medicine, Edinburgh University, UK, Keith A Fox| University of Edinburgh, Cardiovascular Research Unit, Royal Infrmary of Edinburgh, UK
Keywords
Related Articles
- EP ID EP13898
- DOI -
- Views 322
- Downloads 12
Perceived Benefts of Pre-Clinical Simulation-based Training on Clinical Learning Outcomes among Omani Undergraduate Nursing Students
Objectives: Tis study aimed to explore the benefts perceived by Omani undergraduate maternity nursing students regarding the effect of pre-clinical simulation-based training (PSBT) on clinical learning outcomes. Metho...
Re: Biomedical Publications Profle and Trends in Gulf Cooperation Council Countries
Evaluation of Mitotic Figures and Cellular and Nuclear Morphometry of Various Histopathological Grades of Oral Squamous Cell Carcinoma: Comparative study using crystal violet and Feulgen stains
Objectives: The objectives of this study were to quantitatively estimate the number of mitotic figures (MFs) and evaluate the cellular and nuclear features of various histological grades of oral squamous cell carcinoma (...
A Study of Stress among Students of Professional Colleges from an Urban area in India
Objectives: Various studies across the globe have emphasised that students undertaking professional courses, such as medical and dental studies, are subjected to higher stress. Excessive stress could lead to psychologi...
Renal Tuberculosis Presenting as a Mass Lesion in a Two-year-old Girl Report of a rare case
Genitourinary tuberculosis usually occurs in young adults and the middle-aged and is very uncommon in the paediatric population. It generally presents with haematuria, pyuria, irritative voiding symptoms and flank pai...