SERUM LIPID PROFILE ANALYSIS IN PATIENTS WITH ORAL LEUKOPLAKIA
Journal Title: Advance Research Journal of Multidisciplinary Discoveries - Year 2019, Vol 33, Issue 33
Abstract
Background: Oral cancer is preceded by potentially malignant disorders. Oral Leukoplakia is one of the best-known pre-malignant lesions in the oral cavity that has the highest rate of malignant transformation. Literature shows numerous studies have been conducted on an altered lipid profile in head and neck cancers. An inverse relationship between serum lipid profiles has been seen in oral cancer and precancer. The present study was done to evaluate the serum lipid profiles in oral leukoplakia cases. Aim and objectives: To evaluate the alteration in serum lipid profile in patients with oral leukoplakia. Materials and method: The study was conducted on 20 oral leukoplakia cases and 20 controls. Lipid profile included analysis of total cholesterol (TC), low density lipoprotein cholesterol (LDL), high cholesterol (HDL), very low density lipoprotein cholesterol (VLDL), triglycerides (TG) and ratio of high and low density lipoprotein cholesterol. Lipid profiles were measured using the standard reagents. Results: TG, LDL & VLDL were more in males in both groups. TC and HDL levels were highest in females, but were non significant. A significantly reduced serum level of HDL, VLDL, TGL, TC and LDL were also reduced in the oral leukoplakia group. TGL were highest in patients who had mild dysplasia and lowest TC, while, moderate dysplasia cases had highest TC and lowest TG, LDL, VLDL, HDL. Conclusion: The reduced levels of lipid profile in cases of leukoplakia could be due to tobacco habits that reduced the lipid fractions. The reduced levels of lipid in oral leukoplakia could be used to assess the malignant transformation that could help in early detection and prevent the progression to carcinoma.
Authors and Affiliations
Pradkhshana Vijay, Nilesh Pardhe, Shaleen Chandra, Shalini Gupta, Supriya Sharma, Priyanka Singh
Keywords
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