Serum osteocalcin: A potential biomarker for primary osteoporosis
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 3
Abstract
Osteoporosis is a silent killer usually asymptomatic and noticed only after a fracture Women irrespective of their origin and social strata show an accelerated phase of bone loss for about 10 yrs after the cessation of ovarian function due to hormonal imbalance Until now for the diagnosis of osteoporosis Bone mineral density BMD and DEXA was used which is costly hence bone turns over markers have come to vogue in suggesting the risk of osteoporotic fracturesObjectives of the Study To assess the potentiality of serum osteocalcin as a diagnostic tool for osteoporosis in post menopausal women and thus overcome the risk of fracturesMaterials and Methods This study was conducted on 50 apparently healthy pre menopausal women and 50 postmenopausal women with immediate fractures sustained as a result of trivial traumaResults The mean serum osteocalcin level was 263 176 in the post menopausal women with fractures as compared to the pre menopausal women 555 292 which was statistically significantp value Conclusion Osteocalcin is a highly sensitive bone formation marker and can be used as a diagnostic or screening tool in post menopausal women for Osteoporosis The decreased serum osteocalcin levels after menopause could hence predict and prevent the risk of fracturesKeywords Osteocalcin Premenopausal women Postmenopausal women with fractures Calcium Phosphorous Alkaline phosphatase Total protein Albumin and osteoporosis
Authors and Affiliations
Mayur Rai, Tirthal Rai, Srinidhi Rai, Janice D’Sa, Parinita K
Keywords
Related Articles
- EP ID EP475186
- DOI 10.18231/2394-6377.2018.0082
- Views 74
- Downloads 0
Reduced urinary calcium creatinine ratio - can it be used as an early predictor of hypertensive pregnancies?
Introduction: Pregnancy induced hypertension (PIH) is a multifaceted syndrome with involvement of several important organs and it is associated with endothelial dysfunction. The results from many clinical studies show th...
Study of serum copper and zinc levels in association with albumin and uric acid as antioxidant markers in type II diabetes mellitus
Introduction: Type II Diabetes mellitus (type II DM) is a chronic metabolic disorder characterised by oxidative stress. Free radicals play a pivotal role in the progression of diabetes and its complications. The role of...
A study of serum iron level and oxidative stress in the steady state of sickle cell of anaemia
Background: Sickle cell anaemia (SCA) is a hereditary disorder, associated with severe haemolytic anaemia, periodical vasooclussive pain, and premature death. Prevalence of SCA is alarmingly high in north Maharashtra com...
Serum 25- Hydroxy Vitamin D levels in Type 2 Diabetes Mellitus- A Comparative study
Background: Type 2 diabetes mellitus (DM) is a disease of impaired carbohydrate metabolism. Vitamin D deiciency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geogra...
Assessing the utility of serum Cholinesterase, Lactate dehydrogenase and Albumin/Globulin ratio in differentiating liver diseases
Introduction: Variety of liver diseases including alcoholic liver disease (ALD) is responsible for liver related morbidity and mortality in India. Distinguishing ALD from non-alcoholic steatohepatitis (NASH) and viral he...