Serum sE-selectin Levels in Newly Diagnosed Psoriasis Patients and Correlation with Psoriasis Area and Severity Index Score
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 11
Abstract
Introduction: Psoriasis is a chronic skin disorder with unknown aetiology affecting 125 million people worldwide. It is an inflammatory T-cell mediated disease. Few studies have reported increased expression of numerous adhesion molecules (ICAM-1, ICAM-3, sE-selectin) in the psoriatic skin. But whether they can be used as a marker of severity of the disease and immunotherapy targets is still questionable. Aim: To study the levels of sE-selectin in patients with psoriasis and correlate the sE-selectin level with disease severity. Secondly, to see the effect of six months of topical therapy i.e coal tar, salicylic acid and dithranol on sE-selectin levels. Materials and Methods: A descriptive cross-sectional hospital based study was conducted in the Department of Pathology in collaboration with the Department of Dermatology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India. A total of 52 newly diagnosed cases of psoriasis, attending the Dermatology OPD of Smt Sucheta Kriplani Hospital were included in the study group and severity score was calculated. Venous blood sample was taken from 52 patients and 30 age and sex matched controls comprising of healthy, non psoriatic volunteers with no family history of psoriasis. Blood sample was analysed for sE-selectin levels by ELISA (DIACLONE, France). Cases were followed at six months interval to study changes in sE-selectin levels after topical therapy. Statistical analysis was done using SPSS version 19.0. Paired t-test, ANOVA and pearson’s correlation coefficient was used for statistical analysis. Results: The levels of sE-selectin were significantly raised in the cases as compared to controls, correlated with disease severity and showed a reduction in the patients in which follow up was available. After six months of coal tar, salicylic acid and dithranol treatment, there was decrease in mean Psoriasis Area and Severity Index (PASI) and serum sE-selectin but not enough to reach a statistical significance. Conclusion: The sE-selectin levels are raised in patients of psoriasis and show reduction following therapy. They may be attractive targets for newer therapies in the future.
Authors and Affiliations
Dr. Shveta, KIRAN Agarwal, Shilpi Agarwal
Keywords
Related Articles
- EP ID EP366032
- DOI 10.7860/JCDR/2017/29957.10831
- Views 73
- Downloads 0
Carcinoma Cervix Presenting as Ischaemic Stroke in Young Female: A Case Report and Review of Literature
Stroke is a disabling disease which increases the burden of already suffering cancer patients. Several mechanisms of stroke exist in cancer patients which includes - metastatic or non-metastatic such as coagulation disor...
Idiopathic Unilateral Gynaecomastia in Prepubertal Age: A Rare Presentation and Review of Literature
ABSTRACT Unilateral idiopathic gynaecomastia of prepurtal age is a rare presentation. Complete evaluation of unilateral gynaecomastia should be done to identify etiology. We managed a case of unilateral gynaecomastia in...
Metabolic Syndrome in Psoriasis among Urban South Indians: A Case Control Study Using SAM-NCEP Criteria
Introduction: Psoriasis is a chronic inflammatory disease of the skin associated with increased cardiovascular morbidity. Metabolic syndrome is a significant forecaster of cardiovascular events. Aim: To assess the associ...
Communicable Diseases Pattern in Religious Mass Gatherings: A Systematic Review
ABSTRACT Introduction: Religious mass gatherings annually attract many pilgrims from around the world. Spread of communicable disease is one of the challenges of religious mass gatherings. Aim: To develop an understandin...
Assessment of Insulin Sensitivity and its Convalescence with Dietary Rehabilitation in Undernourished Rural West Bengal Population
Introduction: Metabolic syndrome involving diabetes is acquiring the eminence of prospective epidemic in India with dramatic rise in rural population prevalence where majority are undernourished and creates significant h...