SERUM TRACE ELEMENTS (COPPER, MANGANESE AND ZINC) STATUS OF PSYCHIATRIC PATIENTS OF FEDERAL NEUROPSYCHIATRIC HOSPITAL, ENUGU NIGERIA.
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 10
Abstract
Introduction. Trace elements play major roles in various metabolic pathways and are usually associated with an enzyme or another protein as an essential component or they function as cofactors. Alterations in the optimum levels of trace elements may adversely affect biological processes and are associated with many diseases. A few investigators have reported serum trace element levels in some psychiatric disorders. Aim. In this study, we determined the trace element status of psychiatric patients and the effect of drug treatment. Result. The mean serum copper and manganese of the controls were significantly lower than those of the drug-naïve subject (p< 0.0001) while it showed no significant difference from that of the patients on drugs, (p>0.05). A similar result was obtained for manganese. The mean serum zinc level of the control was higher than that of the drug-naïve patients, (p<0.0001) and almost same as that of the patients on drugs, (p>0.05). Conclusions. Drug-naïve psychiatric patients have elevated mean copper and manganese levels but decreased zinc level while those on drugs have near normal levels of all three elements when compared with control values. Since drugs that relieve symptoms affect the serum levels of these trace elements, one can surmise that these elements play some role in the pathogenesis or pathology of mental disorders. Their routine measurement, therefore may aid in the drug management of mental disorders.
Authors and Affiliations
Ogbu Innocent S. I.
Keywords
Related Articles
- EP ID EP629075
- DOI -
- Views 151
- Downloads 0
PREVALENCE OF HYPERTENSION IN PREGNANT WOMEN OF CHILD BEARING AGE ATTENDING KHAMIS MUSHAYAT HOSPITAL, KSA
Introduction: Hypertension affects 10% of all pregnancies and is accompanied by an increase in fetal and maternal morbidity and mortality. Hypertension in pregnancy includes a wide spectrum of conditions, including pre-e...
VIRUCIDAL AND ANTIVIRAL POTENTIAL OF L-AMINO ACID OXIDASE AND Β PROPIOLACTONE AND RELATED RIFT VALLEY FEVER VACCINE POTENTIALS
Regarding the bioactivity of synthetic beta propiolactone (βPL) and natural L- amino acid oxidase (LAAO), derived enzyme from snake venoms, it was chance to study the effect as virucidal and antiviral agent for the expec...
LAPAROSCOPIC RESECTION OF A SIGMOID COLO - VESICAL FISTULA
Colo vesical fistula can be a result of a variety of conditions. Patients commonly present with lower urinary tract symptoms (LUTS) and recurrent urinary tract infections (UTI).The management is surgical resection. Urina...
RELIABILITY OF SCFHS PROGRAMME ASSESSMENT TOOLS 7 YEARS EXPERIENCE OF QASSIM FAMILY MEDICINE DIPLOMA PROGRAMME 2009-2016
Background: Assessment has long played a central role in medical education at all levels of training. There are likely two broad reasons for this prominence and can assure the public of acceptable levels of competence am...
PERIODONTITIS: PROGRESSION AND TREATMENT APPROACHES: A REVIEW
Development of nanotechnology in prescription has changed the pharmaceutical industry. It has effectively cleared numerous obstacles related with different delivery systems, for example, traditional techniques, microsphe...