Serum vascular endothelial growth factor-New scientific role in obesity
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 2
Abstract
Background and Objectives: Obesity and related ailments are a major hassle across the world for many decades now. As per the published data from various sources overweight population between 1976 to 2002, [body mass index (BMI) ≥ 25 kg/m] in the USA has seen a steady increase from 46 to 66% along with the increase in that of obesity (BMI ≥ 30 kg/m2) from 15 to 31%.(1) Vascular endothelial growth factor (VEGF) is known factor in regulation of angiogenesis and tissue remodeling. It has been evident through various publications, the potential role VEGF plays in the control of energy metabolism and adipose tissue.(2) The current study is planned to be carried out in order to investigate clinically the correlation between blood serum VEGF concentrations with BMI and waist circumference in obese and lean subjects. The study was carried out on 30 obese subjects (overweight BMI between 25-29 kg/m2 and obese BMI >30 kg/m2) and 30 matching age and gender lean subjects (BMI < 25 kg/m2). Sandwich ELISA method was used to measure Serum VEGF. The measured values depicted mean and standard deviation of serum VEGF levels as 99.6±5. 1ng/mL in obese and 51.9 ± 7.2ng/mL in lean subjects [p value <0.005]. It was observed that increased levels of vascular growth factors were present in obese subjects compared to lean subjects. This may help protect against obesity and insulin resistance. With this new scientific evidence, we understand the importance of VEGF on the design of new treatment for obesity, obesity-related disorders and insulin resistance.
Authors and Affiliations
Shilpa K. Shet, H. L. Vishwanath
Keywords
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- EP ID EP296834
- DOI 10.18231/2394-6377.2017.0036
- Views 77
- Downloads 0
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