Serum VEGF as a Marker of progression of Hepatitis C Virus Induced liver Disease in Egyptian Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4
Abstract
Background: Hepatitis C virus (HCV) results in inflammatory liver damage. Angiogenesis has been reported to play an important role in the liver damage. Vascular endothelial growth factor (VEGF) is an important proangiogenic factor which induces endothelial cell proliferation, migration and survival. Aim of the work: To evaluate VEGF as a marker of progression of HCV induced liver disease in Egyptian patients. Methods: This study was conducted on 80 patients and 20 controls (Group5). The Patients were classified into 4 Groups: 20 with chronic hepatitis C infection with no evidence of cirrhosis by fibroscan (Group 1), 20 with Child A (Group 2), 20 with Child B (Group 3) and 20 with Child C liver cirrhosis (Group 4). Severity of liver disease was evaluated by the child Pugh score. Liver cirrhosis was diagnosed by ultrasound. Serum levels of VEGF were determined by enzyme linked immunosorbent assay (ELISA). HCV RNA quantification was performed by quantitative real time PCR. Results: There was significant elevation of VEGF in HCV infected patients when compared to controls with p value < 0.001. There was statistically significant difference in median VEGF among the studied groups with p value < 0.001 (median of VEGF in Groups 1, 2, 3, 4 and 5 was 544.4, 634.6, 1003, 1410 and 177 pg/ml, respectively). Significant correlation was noted between VEGF and serum albumin and prothrombin time. Conclusion: serum VEGF can serve as a marker of progression of HCV induced liver disease. VEGF also correlates with hepatic synthetic function as reflected by serum albumin and prothrombin time.
Authors and Affiliations
Shereen Abou Bakr Saleh
Keywords
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