Severe Mood Labilityand Depression in an Adolescent Girl with a MethylenetetrahydrofolateReductase GeneMutation
Journal Title: International Journal of Contemporary Research and Review - Year 2017, Vol 8, Issue 1
Abstract
MethylenetetrahydrofolateReductase (MTHFR), an enzyme that controls the rate of production of N-methyltetrahydrofolate(a molecule which is necessaryfor the N-methyltetrahydrofolate-homocysteinemethyltransferase reaction),is vital for many of the human body’s biological processes, including DNA and RNA synthesis.Mutationsin the MTHFR gene, which have far reaching effects on the negative feedback systems that regulate nucleic acid synthesis (via thymidylate synthesis)and homocysteinelevels,are believed to beof clinical significance and havebeen widely studied. The neurologicaland neuro-psychiatric consequences of these changes have been long suspected but have only recently begun to be characterized. In this case report we discuss M., a fourteen-year-old Caucasian girl with a past diagnosis of major depressive disorder, and a recent history of suicide attempt by overdose, who presentedfor inpatient hospitalization after attempting to drownherselfin a bathtub. A psychiatric history revealed that the patient developed severe depression and mood lability after her fourteenth birthday, which rapidly progressed to suicidal thoughts and two suicide attempts, and it was discovered upon taking a medical history and ordering genetic testing that she carriedtwo MTHFR mutations, in locations where polymorphisms are suspected to correlate to mental illness generally and to mood disorders specifically
Authors and Affiliations
Bradley Brown*, MD, SrinivasaPanuganti, Theodor Rais, MD
Keywords
Related Articles
- EP ID EP312671
- DOI 10.15520/ijcrr/2017/8/1/65
- Views 46
- Downloads 0
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