Sex steroids of blood in cows with purulonecrotic lesions of lower limbs during the reproductive cycle
Journal Title: Біологія тварин - Year 2015, Vol 17, Issue 4
Abstract
The research objects were productive cows of Black Spotted Ukrainian Milk and Holstein breeds. Hormones in the blood of healthy cows were determined with immunofermental analysis during pregnancy (3rd, 5th and 9th months), the postnatal period (5–10th, 15–20th days) and on 60th–65th day postpartum. Obtained results were considered as control and compared to such in cows with diagnosed purulonecrotic lesions of lower limbs such as sole ulcers, ulcers of interdigital space, coronary band phlegmone, purulent pododermatitis. It was discovered that the establishment of orthopedic pathology comes with steroidogenesis disorder. Both general sex hormones and the dynamics of their equilibration were registered. In cows with diseased limbs the reduced concentrations of progesterone and estradiol were observed during pregnancy. In particular, the difference between these indices and control indices was 16.6 % (2.71±0.13 ng/ml) and 24.2 % (39.7±3.7 pg/ml) in the third month, 32.8 % (2,01±0.18 ng/ml) and 23.2 % (30.5±1.6 pg/ml) in the fifth month and 26.4% (0.09±2.51 ng/ml) and 59.1 % (33.8±1.2 pg/ml) in the seventh month respectively. Before the birth an inhibition of steroidogenesis occured resulting in low levels of estradiol (48.8±2.29 pg/ml) with high concentration of progesterone (2.41±0.05 ng/ml) in background. In the first 5–10 days after birth the progesterone level decreased 1.2 times (1.97±0.30 ng/ml), during 20 days a further slight decrease of it was noted and after 60–65 days it reached its minimal index — 1.44±0.63 ng/ml. At the same time, the estradiol concentration in this period was less than controls at 68.5 % (6.2±0.7 pg/ml), in 15–20 days after birth it was less at 62.4 % (7.6±9 pg/ml) and on 60–65th day — at 48.2 % (11,6±4,6 pg/ml). Dynamics of testosterone concentrations in cows with orthopedic damages was almost identical to the control group but the rates were considerably less. In particular, the hormone content was below 1.2 times prior to delivery and at 4.1 and 7.8 times in puerpalny period. Established postpartum decrease of the synthesis of testosterone and estradiol was the evidence of the development of functional ovarian failure. All the mentioned changes became the basis for natal and postnatal pathology and became the common branch of the pathogenesis of associated manifestation of orthopedic and obstetrical diseases.
Authors and Affiliations
S. Vlasenko
Keywords
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