Short chain fatty acids (SCFA), the products of gut bacteria metabolism and their role in the host

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2018, Vol 72, Issue

Abstract

Gut bacterial consortium is essential for the homeostasis of the immune system in mammals. A significant role in maintaining this balance play short-chain fatty acids (SCFA), bacterial metabolites resulting from fermentation of dietary oligosaccharides. The most significant are butyric, propionic and acetic acids present in the microbiome in a specified mole ratio, but these proportions may change due to diet, age, diseases, and other factors. SCFA are the type of messengers between microbiota and immune system. They are responsible for maintaining the balance in the pro- and anti-inflammatory reaction through the set of free fatty acid receptors (GPR). Short chain fatty acids may induce regulatory T-cells (Treg) by an bakteinhibition of histone deacetylase enzyme; the biggest inhibitory potential has butyric acid, causing proliferation and an increase of the functional capabilities of Treg cells. Manipulation of the gut microbiome composition and SCFA level constitutes a promising tool supporting treatment of chronic gastrointestinal diseases associated with an inflammation or caused by dysbiosis due to intensive use of antibiotics.

Authors and Affiliations

Aleksandra Czajkowska, Bogumiła Szponar

Keywords

Related Articles

Searching for new antibiotics – inhibitors of bacterial chromosome replication

The excessive and often unreasonable use of antibacterial drugs leads to rise of antibioticresistant strains. To overcome this problem, new antibiotics are searched and the new drug targets are investigated. The proteins...

Structure of bacterial chromosome: An analysis of DNA-protein interactions in vivo

According to recent reports, bacterial chromosomes exhibit a hierarchical organization. The number of proteins that bind DNA are responsible for local and global organization of the DNA ensuring proper chromosome compact...

Mechanizmy oporności drożdży na stres środowiskowy

Zmiany warunków środowiska stanowią dla komórek drożdży stres. Aby się przed nim obronić komórki wykształciły mechanizmy tolerancji na stres, które uaktywniają się pod wpływem bodźca stresowego. W koordynacji ekspresji g...

Biologiczne skutki stresu oksydacyjnego wywołanego działaniem pestycydów

Pestycydy są powszechnie stosowane do ochrony roślin, produktów roślinnych, a także są wykorzystywane w wielu gałęziach przemysłu. Zaliczane są do związków szkodliwych. Mimo istniejących rygorystycznych kontroli ich st...

Human papillomavirus and its influence on head and neck cancer predisposition

Human papillomavirus (HPV) is a virus often infecting humans. It is often present on skin or mucousmembranes. These diverse DNA viruses are often linked to many various benign and malignant neoplasticlesions. Over 40 typ...

Download PDF file
  • EP ID EP271163
  • DOI 10.5604/01.3001.0011.6468
  • Views 146
  • Downloads 0

How To Cite

Aleksandra Czajkowska, Bogumiła Szponar (2018). Short chain fatty acids (SCFA), the products of gut bacteria metabolism and their role in the host. Advances in Hygiene and Experimental Medicine, 72(), 131-142. https://europub.co.uk/articles/-A-271163