Significance of Immunohistochemistry in Accurate Characterisation of Hodgkin Lymphoma
Journal Title: Journal of Enam Meical College - Year 2015, Vol 5, Issue 1
Abstract
Background: Hodgkin lymphomas are malignant disorders of cells residing in lymphoid tissue and containing Reed-Sternberg (RS) cells and its variants and account for about 0.7% of all new cancers. Hodgkin lymphomas are two types: Classical Hodgkin lymphoma (CHL) that is CD30 positive and CD45 negative in specific pattern; Lymphocyte-predominant Hodgkin lymphoma (LPHL) that is CD30 negative and CD45 positive in specific pattern. Objective: To evaluate the value of immunohistochemistry in the diagnosis and accurate characterisation of Hodgkin lymphoma. Materials and Methods: This cross-sectional study was carried out in the department of Pathology of Sir Salimullah Medical College & Mitford Hospital, Dhaka from January 2010 to June 2012. Histopathologically diagnosed 45 cases of Hodgkin lymphoma and 5 cases of other than Hodgkin lymphoma were selected and then immunomarkers CD30 and CD45 were applied. Results: Among 50 cases 37 were classical Hodgkin lymphoma and 8 cases were lymphocytepredominant Hodgkin lymphoma histopathologically. When immunomarkers were applied in 50 cases then 33 cases were classical Hodgkin lymphoma and 9 cases were lymphocyte-predominant Hodgkin lymphoma. Conclusion: Immunohistochemistry helped in accurate characterisation of Hodgkin lymphoma.
Authors and Affiliations
Mahtab Uddin Ahmed, Harun-Or-Rashid Khan Shilpi
Keywords
Related Articles
- EP ID EP36216
- DOI https://doi.org/10.3329/jemc.v5i1.21493
- Views 302
- Downloads 0
Lipid Profile of Postmenopausal Women with Central Obesity
Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. So, we...
Asymptomatic Hydatid Cyst in a 30-year-old Female
A 30-year-old female presented in the outpatient department of Orthopedics with the history of low backache for 1 month. Physical examination revealed normal findings. A plain radiography of lumbo-sacral spine showed...
Correlation of Index Finger Length (2D) with Height, Weight and BMI in Adult Bangladeshi Male
Background: Human hand is one of the most versatile parts of the human body which plays an important role in modern medical science and evolutionary biology. By virtue of evolution and genetic arrangements, digital len...
Ebola Virus ? A Global Threat
Ebola virus is a filamentous, enveloped, non-segmented, single-stranded, negative-sense RNA virus. It belongs to the Filoviridae and was first recognized near the Ebola River valley in Zaire in 1976. Since then most of...
Images in Clinical Medicine
Abstract not available