Significance of Lactate Levels in Vaginal Fluid with Time of Spontaneous Onset of Labour in Suspected Cases of Pre-Labour Rupture Of Membranes
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 3
Abstract
Background: Prelabour rupture of membranes is reported to occur in 2-25% of all pregnancies. The condition is associated with fetal and maternal infections, cord complications and might be marker of imminent delivery. It is therefore of great importance to accurately confirm the diagnosis and determine the latency period between rupture of membranes and delivery for referral of patients to higher institutions with NICU facilities and thus improve the perinatal outcome. The lactate concentration in amniotic fluid is 4-6 times higher as compared with maternal and foetal blood and hence its level in vaginal fluid can be used to establish prelabour rupture of membranes and time of spontaneous onset of labour in these patients. Objectives: 1. To diagnose prelabour rupture of membranes. 2. To establish the association between lactate levels in vaginal fluid and time of spontaneous onset of labour in cases of suspected prelabour rupture of membranes. Study Design: In this prospective observational study 108 pregnant women with singleton pregnancy of more than 34 weeks of gestation, with prelabour rupture of membranes underwent a sterile speculum examination and vaginal fluid was taken to estimate lactate level. Lactate levels were analysed in Auto analyser using spinreact kit. Then, women were followed till spontaneous onset of labour. Results: The median time of onset of spontaneous labour and examination was 12 hours in patients with lactate levels >5.0mmol/L and 72 hours in patients with lactate levels <5.0mmol/L. Among 55 women with lactate levels > 5.0mmol/L, 65.5% of women (n=36) had spontaneous onset of labour within 24 hours and 85.5% of women (n=47) within 48 hours. The odds ratio of being in labour within 24 hours is almost 18 times higher among women with lactate concentrations > 5.0mmol/L than women with lower lactate levels. Conclusion: A lactate level > 5.0mmol/L is significantly associated with the spontaneous onset of labour within 24 - 48 hours in cases of suspected prelabour rupture of membranes.
Authors and Affiliations
Prof (Dr. ) RizwanaHabib Kant1, Dr. Sabia Rashid, Dr. Mahapara, Dr. Saima Salam4, Dr. Preeti Sharma
Keywords
Related Articles
- EP ID EP389337
- DOI 10.9790/3008-12030496101
- Views 48
- Downloads 0
Probiotic Potential and Virulence Traits of Bacillus and Lactobacillus Species Isolated from Local Honey Sample in Iran
The probiotic potential of bacterial species isolated from local honey samples were analyzed by microbiological, biochemical and molecular methods. A total of 17 Gram positive bacterial isolates were recovered from local...
Seasonal Abundance of Phytoplankton in Relation to PhysicoChemical features of Venkammacheruvu Veeraghattam, Sriakulam(Dist.)A.P, India
Physico-chemical parameters of Venkammacheruvu in Veeraghattam, Andhra Pradesh, have been studied to understand the phytoplankton composition for twelve months (May 2014 to April 2015). A total of 75 genera belongs to fo...
Evaluation of Drugs Used in the Management of Chronic Kidney Disease in a Tertiary Care Teaching Hospital
Chronic kidney disease, a global health problem with possible complications and risk factors besides showing a remarkable negative effect in quality of life. The present study is concerned to evaluate the drugs used in m...
Antihyperlipidemic And Glucose Lowering Effect Of Extract Of Bioregulator Treated Okra (Abelmoschus Esculentus L.) Fruits in Triton-Induced Hyperlipidemia Rats
Extracts from okra have been used to alleviate not only hyperglycemia but also hyperlipidemia in diabetic mice induced by alloxan and streptozocin. However, its hypolipidemic activity has not yet been clearly studied. Th...
Phenological Study Of Two Populations Of Cnidoscolusquercifoliuspohl(Faveleira) In Semiarid Region Of Brazil
The phonological patterns of two populations of Cnidoscolus quercifolius Pohl were evaluated in the caatinga biome western Seridó region of Paraiba State, Brazil. Was analysis represented by activity indices for both pop...