Significance of p53 Gene Expression and Its Correlation with Various Clinico-Pathological Parameters in Head and Neck Squamous Cell Carcinomas
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background: Head and neck cancers are one of the leading cancers by incidence and mortality worldwide, mostly involving the mouth and oropharynx. Despite intense research, its 5-year survival rate remains low. p53 expression has been studied extensively in head and neck squamous cell carcinoms but its utility as a prognostic biomarker is still unclear. Aim: Assessment and clinicopathological correlation of p53 expression in head and neck squamous cell carcinoma. Methods: This prospective study was conducted at Kalinga Institute of Medical Sciences and Pradyumna Bal Memorial Hospital, Bhubaneswar, Odisha in the Department of Pathology for a period of two years and 56 cases were included. p53 expression and its correlation with the various clinicopathological parameters was studied by IHC. The obtained results were analyzed using chi-square test and a p-value of <0.05 was considered significant. Results: In this study out of 56 cases of head and neck squamous cell arcinomas, p53 expression was found in 37 (66.07%) cases. A significant correlation was found between p53 expression and site of origin of the tumour (p=0.014) as well as nodal metastasis (p=0.039). p53 expression did not show any significant correlation with age,sex, the risk factors (alcohol consumption, paan chewing and smoking), grade or tumor staging. Conclusion: p53 expression was observed in majority of cases originating from buccal mucosa and it may serve as a predictor of lymph node metastasis and eventual aggressiveness in head and neck squamous cell carcinomas.
Authors and Affiliations
Chinmayee Panigrahi, Pranati Misra, Kanakalata Dash
Keywords
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- EP ID EP467667
- DOI 10.9790/0853-1802127074.
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