Sildenafil Attenuates Pulmonary Hypertension Following Fat Embolism in an Anaesthetised Rat Model
Journal Title: International Journal of Anesthesiology & Research (IJAR) - Year 2014, Vol 2, Issue 3
Abstract
Release of fat and bone marrow during medullary pressurisation leads to fat embolism and pulmonary hypertension resulting in serious cardiorespiratory complications. This study aimed to determine whether pre-treatment with the phosphodiesterase type 5-inhibitor, Sildenafil, prevents pulmonary artery hypertension in an animal model. The animals either received Sildenafil (5 mg kg-1) or saline intra peritoneally 15 minutes prior to medullary pressurisation with bone cement. Cardiovascular parameters were recorded throughout the procedure. At the end radiopaque contrast was injected into the pulmonary circulation; the lungs were then harvested and imaged using micro CT. Medullary pressurisation in the control animals caused pulmonary hypertension and systemic hypotension. This was associated with a decrease in the area of perfusion of the lungs. These changes were attenuated by pretreatment with Sildenafil. We conclude that in this animal model fat embolism causes similar cardiovascular changes as observed in clinical practice and pretreatment with Sildenafil attenuates these effects.
Authors and Affiliations
Jean-Claude Theis
Keywords
Related Articles
- EP ID EP196928
- DOI 10.19070/2332-2780-1400011
- Views 80
- Downloads 0
Anaesthesia and Analgesia Methods Applied in Thoracic Surgery
Aim: To determine the anaesthesia and analgesia methods applied in thoracic surgery in our clinic and to evaluate these with current literature. Method: A retrospective evaluation was made of patients who underwent surg...
Neurophysiological Monitoring during Surgery on the Central Nervous System: The Role of Evoked Responses
Neurosurgical, orthopedic and vascular interventions may be associated with an inherent risk of ischemia and structural damage to the central nervous system. Along with other modalities used to monitor the intraoperative...
Hemodynamic Influences of Angiotensin-Converting Enzyme Inhibitors on Patients Undergoing Total Knee Arthroplasty With Spinal Anesthesia
Purpose: To determine if patients on angiotensin-converting enzyme inhibitors (ACEIs) had more severe hypotension or required higher doses of vasopressors compared to those who were not on ACEIs under spinal anesthesia f...
Anesthetic Consideration For Laparoscopic Surgery
Minimally invasive surgical procedures aim to minimize the tissue trauma but still achieve a satisfactory therapeutic result. Tissue trauma is significantly less than conventional open procedure. Laparoscopy is the proce...
Postsurgical Chronic Pain: Incidence and Associated Factors in a Latin American Population
Introduction: It is important to know the incidence of Chronic Post-Surgical Pain (CPSP), to describe the distribution of risk and protective factors associated with its presentation and to measure its impact on the qual...