Sildenafil Citrate for Women
Journal Title: Open Access Journal of Reproductive System and Sexual Disorders - Year 2018, Vol 1, Issue 5
Abstract
Sildenafil citrate (SC) is a medicinal drug used to treat male erectile dysfunction and pulmonary hypertension. Sildenafil is a selective and potent competitive inhibitor of the cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase-type 5 (PDE-5) enzymes, which, by preventing the breakdown of cGMP, potentiate the action of NO in tissues that contain PDE-5. Thus, increasing vasodilatation and potentiating the effects of nitrous oxide (NO) on the vascular smooth muscle [1-2]. SC increases uterine blood flow and potentiates estrogen-induced vasodilatation [3]. Sildenafil citrate is metabolized is in the liver by cytochrome P450, the metabolites are: N-desmethylsildenafil (about 50% potency for PDE5). The biological half-life is from 3 to 4 hours, it is excreted in feces and in urine [4]. Sildenafil is developing as a potential applicant for the treatment of intrauterine growth retardation and for premature labor [5]. Sildenafil has also been proposed as a potential therapeutic strategy to maintain placental function in pre-eclampsia [6]. Should sildenafil citrate possess vasodilatory effects in the feto-placental circulation, this would significantly enhance its therapeutic use in treating placental insufficiency. SC has recently been demonstrated not to alter the contractile response to vasoconstrictors or to endothelial dependent vasodilators.
Authors and Affiliations
Mohamed Nabih EL Gharib
Keywords
Related Articles
- EP ID EP639727
- DOI 10.32474/OAJRSD.2018.01.000124
- Views 62
- Downloads 0
Sleep Disorders in Perimenopausal Women and Metabolic Syndrome, is that True?
Sleep disorders (SD) are a common complaint in women going through menopause transition. It is well known that there is a close relationship between SD and one of the main menopausal sympto...
Role of Carbon Mono-Oxide (CO) Signaling During Trophoblast Invasion in Humans
Trophoblast cells originating from the outer tropho ectodermal layer of the blastocyst forms the placenta, a transient organ that is instrumental in supporting pregnancy. The process begins with the interaction between t...
The Impact of Evidence-Based Nursing as The Foundation for Professional Maternity Nursing Practices
Nursing profession is changing emphasis on the use of the best evidence derived from nursing literature in guiding nursing practice, and it has become a global demand. Evidence-Based Nursing (EƁN) is а...
Rupture of Unsacred Uterus in a Primipara (A Case Report)
A 31 years old lady gravid 2 para zero plus one with 39 weeks plus 5 days gestation came to labor and delivery room complaining of lower abdominal pain. She reported that her menstrual cycles were regular bef...
Role of Hysteroscopy (HSY) in the Management of Abnormal Uterine Bleeding (AUB) in women with an Intact Hymen
Background & Objectives: Virginity, is considered as a sign of sexual purity in many societies, and damage to the hymen carries with its serious social implications for patients. Based on these issues & because of (HSY)...