SILIBININ DIHEMISUCCINATE DAMPENS POSTPRANDIAL HYPERGLYCEMIA IN NORMAL RATS CHALLENGED WITH CARBOHYDRATES LOAD: COMPARATIVE STUDY WITH ACARBOSE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
Postprandial hyperglycemia is a major risk factor for diabetic complications leading to disabilities and mortality in diabetics. Silibinin (SDH), a flavonoid, has been tried in traditional medicine for treating many disorders including diabetes. The present study was designed to evaluate the potential of SDH to damp postprandial blood glucose level after maltose and glucose loading in normal rats. Normal, non-diabetic male Albino Wistar rats were treated with 100mg/kg SDH orally to evaluate the effect on postprandial hyperglycemia after carbohydrate loading, using acarbose as comparator. The results clearly showed ameliorated postprandial hyperglycemia due to the use of SDH, it significantly dampened the postprandial hyperglycemia both in maltose and glucose loaded normal rats, greater than control and comparable to acarbose. In conclusion, SDH effectively suppresses postprandial hyperglycemia in normal rats loaded with maltose, which may be attributed to α-glucosidase inhibition, or glucose due to unexplored mechanism.
Authors and Affiliations
Hassan Bushra
Keywords
Related Articles
- EP ID EP97838
- DOI -
- Views 68
- Downloads 0
A REVIEW ON PATHOPHYSIOLOGY, CLASSIFICATION AND LONG TERM COURSE OF DEPRESSION
Depression is an etiologically heterogeneous group of brain disorders characterized by a wide range of symptoms that reflect alterations in cognitive, psychomotor and emotional processes. Depression is a common problem a...
ETHNOMEDICINAL AND PHYTOECONOMIC ELABORATION OF LILOWNAI VALLEY, DISTRICT SHANGLA, PAKISTAN
The flora of Pakistan and especially that of Northren Part has tremendous scope to evaluate their ethnomedicinal importance for more realistic way to justify their traditional usage and applications. Based on this, an et...
DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE AND DESLORATADINE HYDROCHLORIDE IN THEIR COMBINED TABLET DOSAGE FORM
The present manuscript describes new, simple, accurate, and precise high performance thin layer chromatography method for the simultaneous determination of Ambroxol Hydrochloride and Desloratadine Hydrochloride in combin...
THERAPEUTIC SIGNIFICANCE OF QUINOLINE DERIVATIVES AS ANTIMICROBIAL AGENTS
Microbial infections are one of the leading diseases which are responsible for millions of deaths every year because of lack of effective antimicrobial therapy and this situation becomes more complicated because of micro...
STUDY OF THE AVAILABILITY AND AFFORDABILITY OF MEDICINE FOR CHILDHOOD IN SENEGAL
This study surveys the availability of medicines used in the treatment of the diseases of childhood in Senegal and the roles of the pediatric medicinal forms for the treatment of the diseases by the pharmaceutical firm...