Similar Characteristics of Fibrillar form of β-Amyloid Peptide Fractions from Mice Brain affected by Systemic Amyloidosis
Journal Title: International journal of Emerging Trends in Science and Technology - Year 2015, Vol 2, Issue 7
Abstract
Enhanced expression of amyloid β-peptide (Aβ) and deposition is the main causative factor in Alzheimer’s disease (AD). Factors that lead to the genesis of accumulation and toxicity of Aβs are yet to be identified. While studying the effect of systemic amyloid on the functions of the mice brain, it was accidentally found that the mice brains contain accumulated Aβs, which are extractable with hexafluroisopropanol (HFIP) solvent. By purifying with semi preparative HPLC on HFIP extracts, two major fractions containing mixture of Aβs with variable composition were observed. We have characterized these mixtures by electron microscopic and spectroscopic methods. Our results indicate that, the accumulated Aβ fibrils have similar morphological and conformational characteristics as that of Aβs of AD brains.
Authors and Affiliations
Asokan C
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- EP ID EP241083
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