Simulation of Monoclonal Antibody Pharmacokinetics in HumansUsing a Minimal Physiologically Based Model

Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 5

Abstract

The online version of this article (doi:10.1208/s12248-014-9640-5) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Linzhong Li, Iain Gardner, Miroslav Dostalek, Masoud Jamei

Keywords

Related Articles

Targeting opioid receptor heterodimers: Strategies for screening and drug development

G-protein-coupled receptors are a major target for the development of new marketable drugs. A growing number of studies have shown that these receptors could bind to their ligands, signal, and be internalized as dimers....

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

The online version of this article (doi:10.1208/s12248-012-9395-9) contains supplementary material, which is available to authorized users.

Nonviral gene delivery: What we know and what is next

Gene delivery using nonviral approaches has been extensively studied as a basic tool for intracellular gene transfer and gene therapy. In the past, the primary focus has been on application of physical, chemical, and bio...

Current industrial practices of assessing permeability and P-glycoprotein interaction

Combination of the in vitro models that are high throughput but less predictive and the in vivo models that are low throughput but more predictive is used effectively to evaluate the intestinal permeability and transport...

Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics

With the advancement of biotechnology in the last two decades, optimized and novel modalities and platforms of biologic moieties have emerged rapidly in drug discovery pipelines. In addition, new technologies for deliver...

Download PDF file
  • EP ID EP681675
  • DOI  10.1208/s12248-014-9640-5
  • Views 79
  • Downloads 0

How To Cite

Linzhong Li, Iain Gardner, Miroslav Dostalek, Masoud Jamei (2014). Simulation of Monoclonal Antibody Pharmacokinetics in HumansUsing a Minimal Physiologically Based Model. The AAPS Journal, 16(5), -. https://europub.co.uk/articles/-A-681675