Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data Journal title: The AAPS Journal Authors: Thierry Wendling, Nikolaos Tsamandouras, Swati Dumitras, Etienne Pigeolet, Kayode Ogungbenro, Leon A... Subject(s): Medicine
Does the Systemic Plasma Profile Inform the Liver Profile? Analysis Using a Physiologically Based Pharmacokinetic Model and Individual Compounds Journal title: The AAPS Journal Authors: Rui Li, Tristan S. Maurer, Kevin Sweeney, Hugh A. Barton Subject(s): Medicine
Application of Absorption Modeling in Rational Design of Drug Product Under Quality-by-Design Paradigm Journal title: The AAPS Journal Authors: Filippos Kesisoglou, Amitava Mitra Subject(s): Medicine
Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site Journal title: The AAPS Journal Authors: Helen Musther, Katherine L. Gill, Manoranjenni Chetty, Amin Rostami-Hodjegan, Malcolm Rowland, Masou... Subject(s): Medicine
Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation Journal title: The AAPS Journal Authors: Huybrecht T’jollyn, Jan Snoeys, An Vermeulen, Robin Michelet, Filip Cuyckens, Geert Mannens,... Subject(s): Medicine
An Extended Minimal Physiologically Based Pharmacokinetic Model: Evaluation of Type II Diabetes Mellitus and Diabetic Nephropathy on Human IgG Pharmacokinetics in Rats Journal title: The AAPS Journal Authors: Gurkishan S. Chadha, Marilyn E. Morris Subject(s): Medicine
Comparison of Deconvolution-Based and Absorption Modeling IVIVC for Extended Release Formulations of a BCS III Drug Development Candidate Journal title: The AAPS Journal Authors: Filippos Kesisoglou, Binfeng Xia, Nancy G. B. Agrawal Subject(s): Medicine
Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain Journal title: The AAPS Journal Authors: Laura Kervezee, Robin Hartman, Dirk-Jan van den Berg, Shinji Shimizu, Yumi Emoto-Yamamoto, Johanna H... Subject(s): Medicine
A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam Journal title: The AAPS Journal Authors: A. R. Maharaj, J. S. Barrett, A. N. Edginton Subject(s): Medicine
Physiologically Based Pharmacokinetic Modelling of Drug Penetration Across the Blood–Brain Barrier—Towards a Mechanistic IVIVE-Based Approach Journal title: The AAPS Journal Authors: Kathryn Ball, François Bouzom, Jean-Michel Scherrmann, Bernard Walther, Xavier Declè... Subject(s): Medicine
A Simplified PBPK Modeling Approach for Prediction of Pharmacokinetics of Four Primarily Renally Excreted and CYP3A Metabolized Compounds During Pregnancy Journal title: The AAPS Journal Authors: Binfeng Xia, Tycho Heimbach, Rakesh Gollen, Charvi Nanavati, Handan He Subject(s): Medicine
Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn Journal title: The AAPS Journal Authors: Yang Chen, Joseph P. Balthasar Subject(s): Medicine
Modelling and PBPK Simulation in Drug Discovery Journal title: The AAPS Journal Authors: Hannah M. Jones, Iain B. Gardner, Kenny J. Watson Subject(s): Medicine
Population-Based Mechanistic Prediction of Oral Drug Absorption Journal title: The AAPS Journal Authors: Masoud Jamei, David Turner, Jiansong Yang, Sibylle Neuhoff, Sebastian Polak, Amin Rostami-Hodjegan,... Subject(s): Medicine
Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data Journal title: The AAPS Journal Authors: Tycho Heimbach, Suresh B. Lakshminarayana, Wenyu Hu, Handan He Subject(s): Medicine