Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 4

Abstract

The online version of this article (doi:10.1208/s12248-012-9395-9) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Yang Chen, Joseph P. Balthasar

Keywords

Related Articles

Chemical Potency and Degradation Products of Medications Stored Over 550 Earth Days at the International Space Station

The online version of this article (doi:10.1208/s12248-015-9834-5) contains supplementary material, which is available to authorized users.

Independence of substituent contributions to the transport of small-molecule permeants in lipid bilayer

Purpose: To explore the independence of functional group contributions to permeability of nonelectrolytes across egg lecithin bilayers. Methods. The transport rates were measured of a series of α-substituted p-me...

The pharmacokinetics of escitalopram in patients with hepatic impairment

The effect of hepatic impairment on the pharmacokinetics of escitalopram was determined by means of nonlinear mixed effect modeling, considering both the Child-Pugh classification (and its components) and cytochrome P450...

A Neutralizing Antibody Assay Based on a Reporter of Antibody-Dependent Cell-Mediated Cytotoxicity

Benralizumab is a humanized anti-IL5 receptor α (IL5Rα) monoclonal antibody (mAb) with enhanced (afucosylation) antibody-dependent cell-mediated cytotoxicity (ADCC) function. An ADCC reporter cell-based n...

Dietary Flavonoids Modulate CYP2C to Improve Drug Oral Bioavailability and Their Qualitative/Quantitative Structure–Activity Relationship

This study aims to improve the drug oral bioavailability by co-administration with flavonoid inhibitors of the CYP2C isozyme and to establish qualitative and quantitative (QSAR) structure–activity relationships (...

Download PDF file
  • EP ID EP681262
  • DOI  10.1208/s12248-012-9395-9
  • Views 72
  • Downloads 0

How To Cite

Yang Chen, Joseph P. Balthasar (2012). Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn. The AAPS Journal, 14(4), -. https://europub.co.uk/articles/-A-681262