Simultaneous Determination of Acetaminophen and Synthetic Color(s) by Derivative Spectroscopy in Syrup Formulations and Validation by HPLC: Exposure Risk of Colors to Children
Journal Title: AAPS PharmSciTech - Year 2015, Vol 16, Issue 3
Abstract
Analytical reagent grade sodium hydroxide and concentrated hydrochloric acid were procured from Qualigens, Mumbai, India. Methanol and acetonitrile (HPLC grade) were purchased from Merck Limited, Mumbai, India. The standards of synthetic dyes viz carmoisine, erythrosine, and sunset yellow FCF were obtained from Bush Boake Allen, Chennai (India). Standard acetaminophen was a gift from Dr Surrendra Reddy, CSIR-Central Drug Research Institute, Lucknow. All the other chemicals used were of highest purity available commercially.
Authors and Affiliations
Shanya Das Rastogi, Sumita Dixit, Anurag Tripathi, Mukul Das
Keywords
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