Simultaneous Determination of Arbutin and Hydroquinone in Different Herbal Slimming Products Using Gas Chromatography-mass Spectrometry
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2018, Vol 15, Issue 3
Abstract
Objectives: The aim of our study was to develop a simple, precise, sensitive and specific method for the simultaneous determination of arbutin and hydroquinone in different herbal slimming products using GC-MS. Materials and Methods: The methanol and aqueous extracts of nine herbal slimming products in Turkey were evaluated for analysis of arbutin and hydroquinone using GC-MS method. Results: The retention times of arbutin and hydroquinone were found as 11.32 and 5.44 min, respectively. The linear ranges in this method were 5-500 ng/mL for arbutin and hydroquinone, respectively. The intra- and inter-day precisions, expressed as the relative standard deviation, were less than 1.94 and 2.73%, determined from quality control samples for arbutin and hydroquinone, and accuracy was within 1.13 and 2.56% in terms of relative error, respectively. The limit of detection and quantification were 0.555 and 1.665 ng/mL for arbutin, and 0.031 and 0.093 ng/mL for hydroquinone, respectively. Conclusion: The developed method can be used for routine quality control analysis of arbutin and hydroquinone in different herbal slimming products.
Authors and Affiliations
Benan DURSUNOĞLU, Hafize YUCA, Zühal GÜVENALP, Sefa GÖZCÜ, Bilal YILMAZ
Keywords
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- EP ID EP421236
- DOI 10.4274/tjps.38258
- Views 126
- Downloads 0
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