Simultaneous determination of Propranolol hydrochloride and Hydrochlorothiazide in Tablets formulation using spectrophotometric technique (Simultaneous Equation Method)
Journal Title: International Journal of Advances in Scientific Research - Year 2015, Vol 1, Issue 1
Abstract
A new spectrophotometric method was developed for simultaneous determination of compounds with interfering spectra in binary mixtures without previous separation, showing significant advantages over the conventional methods regarding minimal data manipulation and applicability. The proposed method was applied for the determination of Propranolol hydrochloride and Hydrochlorothiazide in Tablets formulation, for determination of sampling wavelength, 10 μg/ml of each of PRO and HCT were scanned in 200-400 nm range and sampling wavelengths were 289 nm for PRO and 270 nm for HCT are selected for development and validation of simultaneous equation method. For this method linearity observed in the range of 10-50 μg/ml for PRP and 5-25 μg/ml for HCT, and in their pharmaceutical formulation with mean percentage recoveries100.13± 0.86 and 100.07± 0.58, respectively. The method was validated according to ICH guidelines and can be applied for routine quality control testing.
Authors and Affiliations
Bhadresh V Savaj, Hasumati A. Raj, Rajanit V Sojitra, Paras Virani
Keywords
Related Articles
- EP ID EP327288
- DOI 10.7439/ijasr.v1i1.1769
- Views 181
- Downloads 0
Zero order and area under curve spectrophotometric methods for determination of Levocetirizine in pharmaceutical formulation
Simple, fast and reliable spectrophotometric methods were developed for determination of Levocetirizine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The qua...
Model for Predicting and Analyzing the %Fe Removed as Deleterious Element from Al-Si alloys During Fe Removal Processing with Mn
Model equation for predicting and analysing %Fe removed from a eutectic Al-Si alloy during Fe removal processing with Mn under controlled conditions has been derived and validated. The model derived; % Fe removed = +1.30...
A review on theoretical models of suicide
Suicide is a major public health issue which is highly complex and multifaceted. Subsequently, after the pioneering work of Durkheim and Freud, researchers and scholars have attempted to explain the biological, social, a...
Effect of compost, cow dung and NPK 15-15-15 fertilizer on growth and yield performance of Amaranth (Amaranthus hybridus)
Nigerian soils are generally low in fertility and enhanced crop yield is only possible through external use of organic and inorganic fertilizers. The present study was carried out under field condition at Teaching and Re...
Formulation and evaluation of Nateglinide dispersible tablet by direct compression method
The study was carried to formulate and evaluate dispersible tablet dosage form obtaining Nateglinide. Nateglinide is a drug for the treatment of type 2 diabetes. The present study is an attempt to select best possible co...