SIMULTANEOUS ESTIMATION OF ATENOLOL AND AMLODIPINE BESYLATE IN TABLETS FORMULATIONS BY VIERODT’S METHOD USING U.V.SPECTROPHOTOMETRY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
A new UV- Spectrophotometric method has been developed for the simultaneous estimation of atenolol and amlodipine besylate in tablet dosage forms using 0.1N hydrochloric acid (pH 1.2). The method is based on simultaneous equation or Vieordt’s method. The λmax values for atenolol and amlodipine besylate were found to be 224.6 nm and 239.6 nm respectively. The system obey Beer’s law in the range of 4-28 µg/ml and 4-32 µg/ml with correlation coefficient of 0.9991 and 0.9932 for atenolol and amlodipine besylate respectively. Intraday and Interday precision were found to be 0.08577-1.4682, 0.1080-1.71138, 0.2525-1.6080 and 0.2599-1.3906 respectively. The developed method can be successfully employed for the assay of atenolol and amlodipine besylate in different formulations.
Authors and Affiliations
Girdhari Jha , Prabhakara Prabhu , Pankaj Kumar , Annu Kumari , Marina Koland
Keywords
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