Simultaneous estimation of canagliflozin and metformin hydrochloride in tablet dosage form by UV spectrophotometry
Journal Title: International Journal of Pharmaceutical Chemistry and Analysis - Year 2018, Vol 5, Issue 2
Abstract
The combination of Canagliflozin and Metformin was available as fixed dose tablets for the treatment of type 2 diabetes The present method aims to develop a simple precise and accurate spectrophotometric method for simultaneous determination of Canagliflozin and Metformin in commercial formulation The method utilizes Vierordts equation based on the measurement at two wavelengths 290nm max of Canagliflozin and 236nm max of Metformin The method exhibited linear range of 25 to 15gml and 5 to 175gml for Canagliflozin and Metformin respectively with a correlation coefficient of 0999 The LOD and LOQ for Canagliflozin were found to be 043 and 131 respectively For Metformin the LOD and LOQ were found to be 049 and 149 respectively The recovery of Canagliflozin and Metformin were found to be 9943 and 9882 respectively The results were validated statistically as per ICH guidelines and were found to be satisfactory To conclude the developed UV spectrophotometric method is more economical for analysis of Canagliflozin and Metformin in both bulk and pharmaceutical dosage form for routine analysisKeywords Canagliflozin Metformin Vierordts equation UVSpectrophotometry ICH guidelines
Authors and Affiliations
D. Sharmila, J. Chandini, K. Vasantha Lakshmi, Ch. Hari Balaji, A. Lakshmana Rao
Keywords
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- EP ID EP481442
- DOI 10.18231/2394-2797.2018.0015
- Views 68
- Downloads 0
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