SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF PARACETAMOL AND CODEINE
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 4
Abstract
A novel, accurate, and simple UV – spectrophotometric method for simultaneous determination of paracetamol (PCM) and codeine (COD) in mixture of standard and tablets formulation was verification in this work without any separation method between the two drugs. The maximum absorbance of drugs in mixture was found to be at ( 243 nm and 278 nm) for PCM and COD respectively, in deionized water: acetonitrile mixture (90:10 v/v) as solvent. These wavelengths were selected for the analysis of drugs as mixture standard and formulated samples. The purposed method is linear in the concentration range of ( 0.3 – 30 μg/mL) for PCM and COD in the mixture respectively, with R2 values of (0.9993, 0.9995 ) for PCM and COD. Recovery means were found to be (99.04, 100.53 ) for PCM and COD respectively. The method was applied for the estimation of the active gradient of the drugs in different samples of formulated dosage. The accuracy of method was validated by mean percentage recovery which was found to be in the acceptable range.
Authors and Affiliations
Dr. Ahmed Mahdi Saeed
Keywords
Related Articles
- EP ID EP636030
- DOI -
- Views 132
- Downloads 0
EFFECT OF ALLIUM SATIVUM ESSENTIAL OIL ON THE GLYCEMIC CONTROL AND HYPERLIPIDEMIA IN TYPE 2 DIABETES MELLITUS SUBJECTS
Background: Allium sativum (AS) is used as herbal medicine since time immemorial. Allium sativum has shown anti- hyperglycemic, anti oxidant, anti cancer, and anti atherogenic activity. Objective: To analyze the glycemic...
SECONDRY METABOLITS OF INULA CASPICA
The chemical constituents of the flavonoids, terpenoids, coumarins and sterols of Inula caspica (family Asteraceae) aerial parts, growing in Uzbekistan was investigated by column chromatographic methods to isolate eight...
HIGH RESOLUTION ULTRASOUND OF FASCICLES IN THE ULNAR AND MEDIAN NERVES
Background: The objective of this work is to study the nerve fascicles of the ulnar and median nerves at two predetermined sites bilaterally. Methods: Twenty seven healthy volunteers underwent imaging of the median nerve...
A NEW MOLECULE OF WATER-SOLUBLE POLYSACCHARIDE ISOLATED FROM EUCALYPTUS GROWING IN LEBANON
Objectives: To study and compare the chemical structure characteristics of the polysaccharides extracted from leaves of Eucaluptus globulus with chemical structure of fucoidans extracted from Dictyopteris polypodioides b...
EFFECTS OF X-RADIATION ON THE SALIVARY COMPOSITIONS
Background: Saliva plays an important role in maintaining healthy teeth. There are many factors that may affect saliva compositions furthermore the X-radiation. Knowledge about the effects of irradiation on the saliva re...