Simultaneous spectrophotometric methods for estimation of levocetirizine and pseudoephedrine in pharmaceutical tablet dosage form.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 2
Abstract
Two methods for simultaneous estimation of Levocetirizine dihydrochloride (LEVC) and Pseudoephedrine hydrochloride (PSEUDO) in two component solid dosage forms have been developed. The methods employ the application of simultaneous equation and the absorbance ratio (Q-analysis) method. All these methods utilize distilled water as a solvent. LEVC shows maximum absorbance at a wavelength of 231 nm and PSEUDO at 257 nm, where the linearity ranges for LEVC and PSEUDO were 5-30 μg/ml and 120-960 μg/ml, respectively. Determination of ratio of absorbance at 231 nm (the maximum absorption of LEVC) and isobestic wavelength 242 nm, the linearity ranges for LEVC and PSEUDO were 5- 30 μg / ml and 120-960 μg / ml, respectively. The procedures were successfully applied for the simultaneous determination of both the drugs in laboratory prepared mixtures and in commercial tablet preparation. The accuracy of the methods was assessed by recovery studies and was found to be ranging from 97.87-99.70% for LEVC and 99.01-99.79% for PSEUDO by the simultaneous equation method, 98.99-101.42% for LEVC and 99.57-99.91% for PSEUDO by the graphical absorbance ratio method.
Authors and Affiliations
Merukar S. S. , Mhaskar P. S. , Bavaskar S. R. , Burade K. B. , Dhabale P. N.
Keywords
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