Six Clinical Predictors for Intractable Childhood Epilepsy
Journal Title: The Journal of Pediatric Research - Year 2019, Vol 6, Issue 3
Abstract
Aim: This study aimed to determine the significance of six clinical predictors associated with medically intractable childhood epilepsy. Materials and Methods: A retrospective cohort study was conducted. A total of 241 children with diagnosed epilepsy were recruited and divided into two groups: 61 patients with intractable epilepsy, and the other 180 patients who responded well to antiepileptic drugs. We investigated seizure semiology, etiology of epileptic encephalopathy, EEG abnormalities and defined the odds ratios (ORs) of predictor factors for intractable childhood epilepsy; age of seizure onset, asphyxia, neonatal intensive care unit (NICU) history, consanguineous marriage, abnormal neuro-imaging, neuropathologic exam, prematurity, parents’ seizure history. Results: According to logistic regression analysis, the major risk factors for intractable childhood epilepsy are (1) neuropathologic examination p=0.000, OR= 58.28 CI= 23.95-141.63; (2) abnormal neuro-imaging p=0.000, OR= 37.55 CI= 16.41-85.94 (3) age of seizure onset p=0.001, OR= 9.43 confidence interval (CI): 3.66-24.3 (4) asphyxia p=0.001 OR= 4.16 CI= 1.75-9.87 (5) consanguineous marriage p=0.001 OR= 3.02 CI= 1.53-5.97 (6) NICU history p=0.003 OR= 2.59 CI= 1.38-4.87 (95% CI). Conclusion: The presented six predictors can be used to determine the medical intractability in children with epilepsy in order to provide early alternative treatment protocols for better seizure control.
Authors and Affiliations
Senem Ayça, Ramazan Deniz Oral, Pınar Erbay Dündar, Muzaffer Polat
Keywords
Related Articles
- EP ID EP656816
- DOI 10.4274/jpr.galenos.2019.93276
- Views 77
- Downloads 0
The Effects of Maternal Anemia in Pregnant Women with Respect to the Newborn Weight and the Placental Weight in the Delivery Room
Aim: The aim of the study was to investigate the possible effects of maternal anemia in pregnant women with respect to placental weight and newborn weight. Materials and Methods: In this cross-sectional study, 68 healthy...
Serum Antioxidative Enzymes Levels and Oxidative Stress Products in Children and Adolescents with Type I Diabetes Mellitus
Aim: Type I diabetes mellitus (TIDM) is an oxidative stress condition in addition to being a chronic metabolic disease. In this study, our aim is to investigate the activity of antioxidative enzymes and the products of o...
Turkish Validity Reliability of the Pediatric Peripheral Intravenous Infiltration Scale and Its Adaptation to Newborns
Aim: The aim of this study is to determine the Turkish validity reliability and newborns’ adaptation to Pediatric Peripheral Intravenous Infiltration Scale. Materials and Methods: This study is methodological and was con...
Diagnostic Value of the Mean Platelet Volume in the Prediction of Respiratory Syncytial Virus in Acute Bronchiolitis
Aim: Respiratory syncytial virus (RSV) is a viral pathogen that causes lower respiratory system infections in childhood. The purpose of this study was to examine whether mean platelet volume (MPV) changes are significant...
Demographic, Phenotypic and Genotypic Features of Alkaptonuria Patients: A Single Centre Experience
Aim: Alkaptonuria (AKU) is an autosomal recessively inherited disease caused by a deficiency of homogentisate 1,2-dioxygenase. This enzyme converts homogentisic acid (HGA) into maleylacetoacetic acid in the tyrosine degr...