Slime production and antibiotic sensitivity pattern of coagulase negative staphylococci isolated from clinical specimens
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 10
Abstract
Background Coagulase negative staphylococci (CONS) have become a common cause of nosocomial infections, particularly bloodstream infections and infections related to the indwelling foreign devices like prosthesis. These organisms when attached to the surfaces of foreign bodies may produce an extracellular slime allowing for the persistence of coagulase negative staphylococci on the catheters. Slime production plays an important role in the pathogenesis and drug resistance of CONS infections. Objective This study was therefore undertaken to know the incidence of CONS in human infections, role of slime production in its pathogenicity and to study antibiogram of the isolates. Materials and Methods 100 strains of CONS isolated from different clinical specimens were taken, identified on the basis of cultural characteristics and were classified into biotypes. Further slime test was done to study production of slime to determine its role in the pathogenicity of CONS. All the isolated strains of CONS were subjected to drug sensitivity by disc diffusion method. Results Maximum age incidence of 35% was in the age group of 21-30 years and minimum incidence of 5% was in the age group of 51-60 years. Out of 100 cases,46 were males and 54 were females with a male: female ratio of approximately 1:1.17. Out of 71 Staph. epidermidis , in 20 cases slime test was positive. Out of 29 cases of Staph. saprophyticus, 2 cases gave slime test positive and in 27 cases, slime test was negative. Slime producing strains of CONS were more resistant to antibiotics like gentamicin and kanamycin in comparison to non slime producing strains. Conclusion Multiple drug resistance has been shown by the slime producing strains of CONS as compared to non slime producing strains thus proving slime production as a marker of pathogenicity in CONS.
Authors and Affiliations
Ashok Kumar, Ananta Singla Avtar Singh Bhullar, Dr. N. S. Neki
Keywords
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- EP ID EP549393
- DOI 10.22192/ijcrms.2018.04.10.001
- Views 178
- Downloads 0
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