Smart nanocarriers for drug delivery: controllable LSPR tuning
Journal Title: Semiconductor Physics, Quantum Electronics and Optoelectronics - Year 2016, Vol 19, Issue 4
Abstract
Gold nanostructures are considered as a potential platform for building smart nanocarriers that will form the basis of novel methods of targeted delivery and controlled release of drugs. However, to ensure maximum efficiency of gold nanoparticles upon the drug release via the plasmon-enhanced photothermal effect, it is necessary to optimize their spectral parameters for operation in the human body that requires both theoretical research and development of appropriate methods for nanostructures fabrication. In this work, mathematical modeling of light extinction spectral dependences for gold nanostructures of different morphology was performed to determine their geometric parameters that provide the occurrence of localized surface plasmon resonance (LSPR) in the red and near infrared regions of the spectrum, where the transparency window of biological tissues exists. Based on the results of previous studies and computer modeling, using hollow gold nanoshells to construct smart nanocarriers was found to be most reasonable. A protocol for production of these nanoparticles based on “silver-gold” galvanic replacement reaction, which is accompanied by a controlled shift of the LSPR wavelength position, was proposed and described in detail. It is shown that the loading of model biomolecules in hollow gold nanoshells significantly changes the output optical parameters of the system under investigation, which should be taken into account for matching with the laser excitation wavelength during the development of smart nanocarriers.
Authors and Affiliations
A. M. Lopatynskyi, V. K. Lytvyn, I. V. Mogylnyi, O. E. Rachkov, O. P. Soldatkin, V. I. Chegel
Keywords
Related Articles
- EP ID EP178428
- DOI 10.15407/spqeo19.04.358
- Views 69
- Downloads 0
Gross–Tulub polaron functional in the region of intermediate and strong coupling
Properties of the polaron functional obtained as a result of averaging the Fröhlich Hamiltonian on the translation-invariant function have been investigated. The polaron functional can be represented in two different for...
Features of electrochemical processes at the boundary p-GaAs–HF water solution
Investigated in this work have been polarization curves typical for the interface p-GaAs–HF water solution with the concentration of fluoric acid between 1 and 10 mass.%. The shape of these curves has been compared with...
Variational approach to the calculation of the lowest Wannier exciton state in wide type-II single semiconductor quantum wells
The possibility to change the spatial character of the Wannier exciton ground state in a wide single type-II semiconductor quantum well has been studied variationally. A heterostructure with the central layer forming a p...
Photoconductivity relaxation and electron transport in macroporous silicon structures
Kinetics and temperature dependence of photoconductivity were measured in macroporous silicon at 80…300 K after light illumination with the wavelength 0.9 μm. The influence of mechanisms of the charge carrier transport t...
Comparison of some different ways used for approximate solution of kinetic equation and calculations of carrier mobility
Consideration of different problems of physical kinetics shows that obtained non-equilibrium distribution function and following kinetic coefficients calculated are significantly dependent on choice of approach to approx...