Smart nanocarriers for drug delivery: controllable LSPR tuning
Journal Title: Semiconductor Physics, Quantum Electronics and Optoelectronics - Year 2016, Vol 19, Issue 4
Abstract
Gold nanostructures are considered as a potential platform for building smart nanocarriers that will form the basis of novel methods of targeted delivery and controlled release of drugs. However, to ensure maximum efficiency of gold nanoparticles upon the drug release via the plasmon-enhanced photothermal effect, it is necessary to optimize their spectral parameters for operation in the human body that requires both theoretical research and development of appropriate methods for nanostructures fabrication. In this work, mathematical modeling of light extinction spectral dependences for gold nanostructures of different morphology was performed to determine their geometric parameters that provide the occurrence of localized surface plasmon resonance (LSPR) in the red and near infrared regions of the spectrum, where the transparency window of biological tissues exists. Based on the results of previous studies and computer modeling, using hollow gold nanoshells to construct smart nanocarriers was found to be most reasonable. A protocol for production of these nanoparticles based on “silver-gold” galvanic replacement reaction, which is accompanied by a controlled shift of the LSPR wavelength position, was proposed and described in detail. It is shown that the loading of model biomolecules in hollow gold nanoshells significantly changes the output optical parameters of the system under investigation, which should be taken into account for matching with the laser excitation wavelength during the development of smart nanocarriers.
Authors and Affiliations
A. M. Lopatynskyi, V. K. Lytvyn, I. V. Mogylnyi, O. E. Rachkov, O. P. Soldatkin, V. I. Chegel
Keywords
Related Articles
- EP ID EP178428
- DOI 10.15407/spqeo19.04.358
- Views 105
- Downloads 0
The phenomenon of magnetic exchange bias in ferromagnetic nanocomposites grown by electron beam evaporation
For the first time, in ferromagnetic nanocomposites Co/СoO/Al2O3 formed by two-crucible electron beam evaporation with deposition on a policor substrate, the magnetic exchange bias was observed. It is associated with the...
Growth of silicon self-assembled nanowires by using gold-enhanced CVD technology
In spite of the fact that, a great deal of experimental research has been published, there is a lack of good understanding of silicon nanowires growth to exert control over important properties of the system, though it p...
Fluorescence of molecules placed near a spherical particle: Rabi splitting
Theoretical study of spontaneously emitted spectra of point-like source placed near spherical Ag particle was performed. It was shown that near-field electromagnetic interaction between a point-like emitter and spherical...
Smart nanocarriers for drug delivery: controllable LSPR tuning
Gold nanostructures are considered as a potential platform for building smart nanocarriers that will form the basis of novel methods of targeted delivery and controlled release of drugs. However, to ensure maximum effici...
Formation of nanostructured state in LaBGeO5 monolithic glass using pulsed magnetic fields
Using the methods of transmission electron microscopy, X-ray structure analysis and thermal differential analysis, it has been discovered that the pulsed magnetic field (PMF) intensifies homogeneous crystallization in La...