Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 2
Abstract
Background: Oxidative stress, inflammation, and hypoxia, which are associated with chronic obstructive pulmonary disease (COPD) may contribute to auditory impairment. Aims and Objectives: The present study was undertaken to assess the brainstem auditory evoked potential (BAEP) of smokers and non-smokers with or without COPD. Materials and Methods: The study comprised smokers with (n = 25) or without COPD (n = 15) and also healthy non-smokers (n = 30). Oxidative stress was assessed by malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP). Pulmonary functions were determined. Data were analyzed using ANOVA and Pearson’s correlation tests. P < 0.05 was considered statistically significant. Results: Spirometric values were significantly lower in COPD group in comparison with other two groups. Oxidant/antioxidant imbalance was more in smokers with COPD. BAEP result (both right and left ear) showed no significant difference between non-smokers and smokers without COPD in Wave I (P = 0.885 and 0.085, respectively) and in wave II (P = 0.554 and 0.396, respectively). Significant difference (both ears) was found between non-smokers and smokers with and without COPD in waves III, IV, V, and IPL I-V. MDA showed significant negative and positive correlations with FRAP, wave latencies, and IPL. Significant negative correlation was found between pack years and FRAP. However, non-significant positive correlation was found with MDA. Significant positive correlation was found between pack years and wave latencies III, IV, and V and interpeak latency I-V in both ears. Conclusion: Smoking-induced oxidative stress as well as increased susceptibility to COPD, which in turn led to hypoxia and effects the auditory mechanisms and these are responsible for BAEP abnormalities.
Authors and Affiliations
Shah Mohammad Abbas Waseem
Keywords
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- EP ID EP450368
- DOI 10.5455/njppp.2018.8.0308617082017
- Views 49
- Downloads 0
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