Sodium Arsenite-Induced Histopathological and Oxidative DNA Damage in the Ovary of Mice
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 5
Abstract
Arsenic is well- known to promote toxicity in the reproductive system.. It alters the ovary of mice at different dose levels. It creates more and more reactive oxygen species (ROS) in the ovary. Female Swiss albino mice were selected as the experimental animal. In the treatment group, 1.8 mg/kg body weight Sodium arsenite and in the control group distilled water was given orally by gavage method daily for 5 months. After the treatment, mice were sacrificed and the ovary and blood samples were collected. Sodium arsenite treated group showed no effects of CA 125 in mice blood, LPO level was significantly (p < 0.01) increased, whereas antioxidant enzymes (SOD and CAT) activity was significantly (p < 0.05 ) decreased as compared to the control group. Apoptotic index was significantly (p < 0.01) higher in arsenic-treated mice compared with the control. Sodium arsenite treated group showed degenerated follicular structure with vacuolated spaces in stroma filled with RBCs in comparison with the histology of control mice ovary. Our the results showed that exposure to Sodium arsenite promoted degenerative changes and caused oxidative stress in the ovary of mice.
Authors and Affiliations
Shailendra Kumar, Preety Sinha
Keywords
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