SOLID DISPERSIONS OF FENOFIBRATE BY DROPPING METHOD
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 11
Abstract
The main objective of the study was to enhance the dissolution of fenofibrate (BCS class II), poorly soluble drug. To improve the solubility of the drug, solid dispersions were prepared by dropping method with PEG 4000 and PEG 6000 in the ratios of 1:1 and 1:2. The formulations were filled into capsules and evaluated for solubility, assay, FTIR, X-ray diffractions, DSC, and in-vitro dissolution. The optimized formulation was compared with the marketed formulation. The optimized formulation D4 (containing PEG 6000 (1:2) by dropping method) showed maximum solubility 0.678 ± 0.07 mg/ml when compared to pure drug (0.018 mg/ml), assay, 98.14 ± 12% and practical percentage yield 95.25 ± 0.17%. In-vitro dissolution studies of the prepared solid dispersions showed release in 60 min whereas D4 formulation released 99.10 ± 0.18% in 30 min when compared to pure drug 27.38 ± 0.10% in 60 min, and a marketed capsule containing micronized fenofibrate (Lipicard) 93.91 ± 0.12% in 30 min. FTIR studies confirmed that there is no interaction between the drug and the excipients. The solid-state characterization of solid dispersion formulation by XRD and DSC studies confirmed that the drug present in the formulation was in an amorphous state. The optimized formulations were found to be stable. Hence, with the dropping method using the least ratio of the carrier (1:2), the percentage release of drug was increased similar to micronized fenofibrate (Lipicard).
Authors and Affiliations
D. Prasanthi et al.
Keywords
Related Articles
- EP ID EP665544
- DOI 10.13040/IJPSR.0975-8232.10(11).4995-01
- Views 105
- Downloads 0
A REVIEW ON CLINICAL EFFICACY OF TRADITIONAL PLANTS ON OSTEOARTHRITIS
Osteoarthritis is accepted as the most growing, frequent, debilitating and heterogeneous condition that worsens the quality of life globally in the elderly, affecting an estimated 10% of men and 18% of women over 60 year...
DEVELOPMENT, CHARACTERIZATION AND IN-VITRO ANTIFUNGAL EVALUATION OF PLANTEROSOMAL GEL OF GANODERMA LUCIDUM
Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifu...
AN UPDATE ON NOVEL TECHNOLOGIES, IN-VITRO AND IN-VIVO MODELS FOR TUBERCULOSIS AND TUBERCULOUS MENINGITIS
Tuberculosis is a bacterial infection which is caused by the bacteria Mycobacterium tuberculosis. It is next to AIDS and causes morbidity and mortality. These bacteria can stay in the host’s body for decades. In this art...
A NOVEL STABILITY INDICATING UPLC METHOD FOR THE ESTIMATION OF TEZACAFTOR AND IVACAFTOR IN TABLET DOSAGE FORM
UPLC is a modern technique which refers to Ultra Performance Liquid Chromatography and enhances in three main areas: Speed, resolution, and sensitivity. In this present study, an accurate and precise UPLC method was deve...
ROLE OF ANDROGRAPHIS PANICULATA ON ALTERED STEROIDOGENESIS AND OXIDATIVE IMPAIRMENT IN OVARY OF MICE SUBJECTED TO ARSENIC INTOXICATION
The present study was designed to determine the role of Andrographis paniculata (AP; 50 mg/kg) against the oxidative stress caused by the arsenic (0.5 and 1.0 mg/kg) for 30 days in adult mice. The results of in-vivo stud...