Solubility enhancement of an antifungal agent by association with dendrimers
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 2
Abstract
Amphotericin B is a polyene antifungal agent which is not freely soluble in water. The clinical use of amphotericin B is limited by nephrotoxicity and poor water solubility, which leads in some cases to permanent renal impairment, especially in the presence of other nephrotoxic drugs. PAMAM dendrimer provides a uniform platform for drug attachment that has the ability to bind and release drugs through several mechanisms. Objectives& Methods: In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers to increase the solubility of amphotericin B. Results: The experimental results suggested that the solubility of amphotericin B was greatly enhanced in the presence of PAMAM dendrimer solutions. Results showed that the solubility of amphotericin B increased with increase in dendrimer concentration as well as generations. In vitro release behavior of amphotericin B in presence of G3 PAMAM dendrimers was performed by dialysis method. Conclusion: Our work demonstrated that encapsulation of amphotericin B into dendrimers led to sustained release of the drug in vitro.
Authors and Affiliations
Jobin Jose, R Narayana Charyulu
Keywords
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