Somatic TP53 mutations and comparison of different TP53 functional domains in human cancers: data analysis from the IARC TP53 database and the National Cancer Institute GDC data portal
Journal Title: Medical Data Mining - Year 2021, Vol 4, Issue 3
Abstract
P53 gene mutations have been known to be highly related to the majority of human cancers. The colocation of biologists and bioinformaticians have constructed many databases for cancer research. Although the relationship between the presence of TP53 mutation and cancers has been reported in various studies, few reports TP53 mutation distribution in different functional domains. Hence, we use 2 databases (The TP53 Mutation Database of the International Agency for the Research on Cancer and The Genomic Data Commons data portal) to compare survival rate with and without TP53 mutations in a certain cancer, as well as to find most frequent mutation sites in different functional domains of the TP53 protein. Our study shows that most somatic mutations of TP53 and high mutation rate sites are concentrated in the DNA-binding domain, and the survival of certain cancers varies with and without P53.
Authors and Affiliations
Juan Du1, Hong-Jian Gong1*, Han Xiao1*
Keywords
Related Articles
- EP ID EP693187
- DOI 10.12032/MDM2021033003
- Views 128
- Downloads 0
Efficacy of high-flow nasal cannula on acute exacerbation of chronic obstructive pulmonary disease: A meta-analysis
Objective: To systematically evaluate the efficacy and feasibility of high-flow nasal cannula (HFNC) on patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: Systematic searches on...
Postulation of a priod of an unexplored manuscript —— Kashyapa Samhita
Fixing the date of an unexplored manuscript is always a challenging task for a research scholar. The chronology of an unpublished manuscript can be postulated based on internal and external evidence. Here is the study of...
The application effect of swaddling bath in neonates: A meta-analysis
Objective: The meta-analysis is to objectively evaluate the efficacy of swaddling in neonates. Methods: Randomized controlled trials (RCTs) and Randomized cross-over design (RCD) about the effects of swaddling in neonate...
Based on data mining, the drug law of clinical treatment of chronic urticaria
Background: Based on clinical data mining, we introduce the medication rule and clinical application of Professor Wang Lifen in the treatment of chronic urticaria, as the reference of clinical treatment of chronic urtica...
Medical Data Mining: the pilot of medical data analysis in the era of big data
Clinical databases have accumulated large quantities of information about patients and their medical conditions. Current challenges in biomedical research and clinical practice include information overload and the need t...