Somatic TP53 mutations and comparison of different TP53 functional domains in human cancers: data analysis from the IARC TP53 database and the National Cancer Institute GDC data portal
Journal Title: Medical Data Mining - Year 2021, Vol 4, Issue 3
Abstract
P53 gene mutations have been known to be highly related to the majority of human cancers. The colocation of biologists and bioinformaticians have constructed many databases for cancer research. Although the relationship between the presence of TP53 mutation and cancers has been reported in various studies, few reports TP53 mutation distribution in different functional domains. Hence, we use 2 databases (The TP53 Mutation Database of the International Agency for the Research on Cancer and The Genomic Data Commons data portal) to compare survival rate with and without TP53 mutations in a certain cancer, as well as to find most frequent mutation sites in different functional domains of the TP53 protein. Our study shows that most somatic mutations of TP53 and high mutation rate sites are concentrated in the DNA-binding domain, and the survival of certain cancers varies with and without P53.
Authors and Affiliations
Juan Du1, Hong-Jian Gong1*, Han Xiao1*
Keywords
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- EP ID EP693187
- DOI 10.12032/MDM2021033003
- Views 114
- Downloads 0
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