Some Haematological Parameters and Immunoglobulin Levels in Mycobacterium tuberculosis Infected Patients in Benin City, Southern Nigeria
Journal Title: International Journal of TROPICAL DISEASE & Health - Year 2017, Vol 26, Issue 1
Abstract
Mycobacterium tuberculosis (MTB) infection is a major public health challenge in Nigeria. This research aims at determining the effect of MTB infections on some haematological and immunological parameters in MTB patients in Benin, Nigeria. One hundred and fifty subjects were recruited for the studies. These subjects comprised of 50 MTB positives, 50 MTB positives on direct observation and treatment (DOTS), and 50 controls. Ethical approval was obtained from the Ethics Committee of Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi campus. Informed consent was obtained from all subjects recruited for the studies. Five milliliters of blood was collected from each subject for HIV test by ELISA method, CD4 count by Flow Cytometeric technique, immunoglobulin test by immune-turbidimetric method, estimation of leucocyte profile by automated haematological analyser and ESR by routine method. In addition, sputum was collected from each subject for Ziehl Neelsen technique of Mycobacterium tuberculosis examination. Statistical Package for Social Science (version 20) was used for the data analysis. Results obtained from the study showed that the comparison of the WBC of the control subjects and MTB positive subjects was significantly higher in the MTB positive subjects (p < 0.05). Also, WBC of Mycobacterium tuberculosis (MTB) positive subjects was significantly higher than MTB positives on DOTS. The CD4 count of DOTS administered MTB positives was significantly higher than non-DOTS MTB positive subjects (p < 0.05). The mean values of immunoglobulin A, G, M (IgA, IgG and IgM) in MTB positive subjects were significantly higher compared with the values in the controls (p < 0.05). Also, IgG value in the DOTS administered MTB positive subjects was significantly higher than the mean value in the control subjects. In same manner, the IgA and IgM value for non-DOTS in each case was higher than MTB on DOTS subjects (p < 0.05). The value of Haematocrit (HCT) and Lymphocyte (LYM) count were significantly higher in control subjects when compared with DOTS administered MTB positives and MTB positives in each case (p < 0.05). The value of neutrophil for MTB positives was significantly higher than the value in the control subjects (p < 0.05). Thus Immunoglobulin G, A, and M could be used as a predictive marker for monitoring MTB infections, alongside haematological parameters and CD4 count.
Authors and Affiliations
Ifeanyichukwu, Martin Ositadimma, C. Meludu Samuel, Odozi, Efeota Bright, Okeke, Chizoba Okechukwu
Keywords
Related Articles
- EP ID EP312647
- DOI 10.9734/IJTDH/2017/25693
- Views 81
- Downloads 0
Barriers to HIV Treatment Adherence: Findings from a Treatment Center in South-South, Nigeria
Aims: Non-adherence to treatment represents a significant challenge to anti-retroviral treatment goals. This study aimed to identify and explore perceived barriers to adherence in non-adherent HIV patients attending the...
Impact of Noise Pollution on Human Cardiovascular System
Noise pollution is one of the man-made environmental hazards that is given the least attention. By World Health Organization’s (WHO) definition, noise pollution is unwanted or excessive sound that can have deleterious ef...
Prevalence of Dental Fluorosis among Secondary School Children in Oloibiri Community
Background: Dental fluorosis with its attendant complication of aesthetic distortion of the teeth has now become another focus of public health intervention worldwide. We studied the prevalence of dental fluorosis among...
Detection and Species Identification of Malaria Parasites by Nested-PCR: Comparison with Light Microscopy and with SD BIOLINE Malaria Ag Test in Luanda, Angola
Background: Malaria is the infectious disease causing the highest morbidity and mortality in Angola. Existing tools for the diagnosis of malaria include microscopy, rapid diagnosis tests (RDTs) and molecular tools. Neste...
Otologic Disorders in Children: Our Experience in a Private Hospital Setting in Port Harcourt, Nigeria
Background: Otologic disorders have been found to be important health problems among children Worldwide. This study was done to establish the pattern of otologic disorders in children as seen in a private hospital settin...