Spectral response аnd electronic structure оf synthetic coumarin derivatives. P a r t IV. Study оf the UV-spectra оf warfarin sodium clathrate
Journal Title: Фармацевтичний журнал - Year 2014, Vol 5, Issue 5
Abstract
Warfarin is a vitamin K antagonist that was first developed by Wisconsion Alunini Research Foundation in 1947. The use of warfarin in the treatment fоr decrease blood clotting, promotes the emergence of a number of side effects. Thus there is vascular fragility resulting suppression factor activity that supports the elasticity of blood vessels. Warfarin has a great affinity with proteins and displaces from connection any drugs, increases a toxicity, dramatically increasing their blood levels in the free state. Study of the UV-spectra of warfarin was carried out using a spectrophotometer SPECORD 200U214 (Germany). Measuring the absorption of test solutions were made in quartz cuvettes with a layer thickness of 10 mm. Measuring the electronic spectra were performed in the range from 200 to 400 nm, and the graphs of spectra has been constructed in the coordinates Α = f (λ). In order to establish the relationship between chemical structure and nature of warfarin's band absorption and to determine the types of electron transitions, we studied the UV-spectra of the substance in twelve solvents with the different polarity. The study of the electronic spectra of warfarin was conducted on the basis of obtaining of the absorption bands in the neutral, polar and low-polar solvents. The spectra of warfarin in water, 95% ethanol and methanol are characterized by two bands of absorption. Electronic spectra in alkaline solvents also have two bands absorption. Spectra of absorption of the substance in solvents acidic nature was characterized by three bands. UV-spectra of warfarin in low-polar solvents (chloroform and acetonitrile) are characterized by two bands absorption. The cyclohexane solutions of the analyzed compounds exhibit three bands of absorption. Based on the results of our study, it must be concluded that the first band of adsorption is the result of π→π*-transitions ¹La-bands of the phenyl radical. The second band of adsorption in medium spectrum is characteristic only of warfarin solutions in solvents of acidic character and refers to ¹Lb-band and also corresponds to π→π* benzene character. The peaks of adsorption spectra within the 305–319 nm certainly arise only as a result of p→π-conjugation the benzene-cycle with enone of molecule warfarin sodium clathrate in all these solvents.
Authors and Affiliations
O. V. Grechana
Keywords
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