Spectrophotometric Analysis for the Quantification of Rivaroxaban in Bulk and Tablet Dosage Form
Journal Title: International Journal of Medicine and Pharmaceutical Sciences (IJMPS) - Year 2017, Vol 7, Issue 5
Abstract
Objective This study reveals the report on the development of two spectrophotometric methods (A and B), for the determination of rivaroxaban in bulk and Xeralto tablets. Methods Method A involves the formation of colored tris (1, 10-phenanthroline)-iron (II) complex, upon reaction of rivaroxaban with iron (III)-1, 10-phenanthroline mixture in acidic media. The colored complex is spectrophotometrically measured at 525 nm. Method B involves the interaction of RXN with acetaldehyde with chloranil, to give colored vinylamino substituted quinones. The colored product exhibit absorption maxima at 655 nm. Effects of experimental variables on the determination of rivaroxaban have been examined and optimized. The proposed methods are validated by following ICH guidelines. Results Beer's law correlating the absorbance with rivaroxaban concentration was obeyed in the range of 5-62.5 μg/ml and 10-100 μg/ml, for methods A and B, respectively. Limits of detection and quantitation values were 0. 101μg/ml and 0.306μg/ml, respectively, for method A, and their respective values for method B were 0.116μg/ml and 0.351 μg/ml. The values of accuracy, precision, selectivity, robustness and ruggedness are within the adequate limit. The proposed method was applied successfully, for the quantification of rivaroxaban in Xeralto tablets, with good accuracy and precision. Conclusion The proposed methods A and B are valuable, in terms of its regular application in quality control assay of rivaroxaban.
Authors and Affiliations
Burla Sunitha Venkata Seshamamba, Chandra Bala Sekaran
Keywords
Related Articles
- EP ID EP245194
- DOI -
- Views 109
- Downloads 0
ANALYSIS OF GROWTH AND SPORULATION OF FILAMENTOUS FUNGI IN DIFFERENT LIQUID MEDIA
Composition of culture medium plays a significant role in growth and sporulation of experimental microorganisms. Preparation of most suitable culture media is one of the prerequisites to investigate them. The aim of the...
Neurosurgical Congenital Anomalies in Basrah Socio Demographic Review
Background: Congenital anomalies, including those of the central nervous system, are among the important leading causes of morbidity, mortality, and fetal loss with a lot of familiesy suffer and misery. OBJECTIVES To stu...
Effects of Acepromazine and Midazolam Along with Ketamin on Haematological Parameters Inyak
The study was conducted to study the effect of acepromazine and midazolam along with ketamin on haematological parameters in yak. Twelve clinically healthy yaks of either sex and below 2 years of age from yak farm of ICA...
GEOGRAPHICAL IMPACTS OF PODOPHYLLOTOXIN (ANTI-CANCER DRUG AGENT) FOUND IN ROOTS OF PODOPHYLLUM HEXANDRUM & YIELD ENHANCEMENT USING PRECURSORS AND ELICITORS: LC-MS/MS METHOD
Podophyllum hexandrum is a well-known medicinal plant, which demonstrates numerous therapeutic effects due to the presence of Podophyllotoxin, especially in Oncology. In this study, after development and validation of an...
Analysis of Drug Contents of Cefotaxime Formulations Available in the Local Market and the Effect of Storage Conditions
Background: Low quality antimicrobial drugs represent a world-wide problem. Beta-lactams are the main types of antimicrobials found to be substandard or counterfeit. Environmental conditions can play an important role in...