Spectrophotometric Determination of Paracetamol Using Sodium bismuthate as Chromogen
Journal Title: International Journal of Research in Chemistry and Environment (IJRCE) - Year 2012, Vol 2, Issue 1
Abstract
A simple and accurate method was developed by the authors for the detection and determination of paracetamol by spectrophotometric method in pharmaceutical formulations in the form of tablets and capsules. Paracetamol was dissolved in 4M sulphuric acid and treated with 10.0 mg of sodium bismuthate in the presence of 1M HCl and 1M acetic Acid. It exhibited a stable bluish-violet colour. The coloured compound showed a λmax at 550 nm. Beer’s law was obeyed in the range of 100-300µgmL-1 in 1M HCl and 300-800 µgmL-1 in 1M acetic acid medium, with detection limits of 0.03µgmL-1 in 1M HCl and 0.05 µgmL-1 in 1 M acetic acid medium respectively. The method developed by the authors was found to be precise and accurate for qualitative and quantitative determination of paracetamol.
Authors and Affiliations
G V S R Kumar, G. Kumar, T. Sekhar , Sreerama Murthy
Keywords
Related Articles
- EP ID EP135927
- DOI -
- Views 105
- Downloads 0
Kinetics and Hydrolysis Mechanism of 2,4-dichlorofenoxyacetic acid
The hydrolytic transformation kinetics of the 2,4-dichlorofenoxyacetic acid (2,4-D) was investigated as a function of pH. The hydrolysis rate was pH-dependent and the first order. The hydrolysis was much faster in acidic...
Caladium Bicolor as Bioadsorbent for Treatment of Industrial Effluents[/b][b][/b]
[i] The uses of low cost substrate have been proposed for the removal of heavy metals from industrial effluent and wastewaters. The study examined the effectiveness of Caladium bicolor (wild cocoyam) leaf for the re...
Photochemical Treatment of Methyl Red Waste Water by Photo-Fenton Reagent
Degradation of commercial textile dye methyl red by photo-Fenton reagent has been investigated under irradiation of visible light in an aqueous medium. The Fenton reaction is a catalytic process for the generation of...
Studies on the Assessment of Toxic Metals Present in Biological Samples (Part-1)
Development in the 20th century has brought social and economic benefits to us but the changes have also caused a wide range of environmental problems at both local and global level. Increased industrial activities has i...
Adsorption modeling of alizarin yellow on Biosorbent casuarina equisetifolla
Adsorption studies of alizarin yellow from an aqueous solution were carried out on casuarina equisetifolla. Casuarina equisetifolla was subjected to various pretreatments. Various parameters such as pH, dosage amount, an...