Spectrophotometric Determination of Risedronate in Pharmaceutical Formulations via Complex Formation with Cu (II) Ions: Application to Content Uniformity Testing
Journal Title: International Journal of Biomedical Science (IJBS) - Year 2008, Vol 4, Issue 4
Abstract
A simple, sensitive, rapid and accurate spectrophotometric method was developed for the determination of risedronate, a bisphosphonate drug important for the treatment of a variety of bone diseases, in raw material and pharmaceutical formulations. The proposed method is based on complex formation between risedronate and Cu (II) ions in acetate buffer of pH5.5. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of risedronate in concentration range of 2-40 µg/mL with detection limit of 0.03 µg/mL (9.51 × 10-8 mol/L). The molar absorbtivity was 8.00 × 103 l/mol/cm. The method was successfully applied for the determination of risedronate in tablet dosage form with mean percentage recovery of 101.04 ± 0.32. The results obtained were favorably compared with those obtained by the comparison method. Furthermore, the proposed method was applied for content uniformity testing of risedronate tablets.
Authors and Affiliations
M. I. Walash, M. E. -S. Metwally, M. Eid, R. N. El-Shaheny
Keywords
Related Articles
- EP ID EP82955
- DOI -
- Views 121
- Downloads 0
Clinical Outcome of High Risk Gastrointestinal Stromal Tumor in a Meckel’s Diverticulum
We describe a seven years follow-up of a high risk gastrointestinal stromal tumor in a Meckel’s diverticulum in a 68-year-old man with abdominal pain and vomiting. The patient was operated in emergency for peritonitis du...
HIV/AIDS Knowledge, Attitudes, and Behaviors of Construction Workers in China
The objective of the study was to describe HIV/AIDS knowledge, attitudes, risk behaviors, and sources of information among construction workers in China. A cross-sectional survey of 458 construction workers was conducted...
Lower-Dose and Long-Term Intermittent Interferon Therapy for Hepatitis C Genotype 2a may be a Possibility
We report two recent, successful cases in treating active chronic hepatitis C patients (genotype 2a) with a lower-dose and long-term intermittent interferon therapy. Case 1: A 67-year-old female received IFN-alpha 3 MU t...
Spectrophotometric Determination of Risedronate in Pharmaceutical Formulations via Complex Formation with Cu (II) Ions: Application to Content Uniformity Testing
A simple, sensitive, rapid and accurate spectrophotometric method was developed for the determination of risedronate, a bisphosphonate drug important for the treatment of a variety of bone diseases, in raw material and p...
Kinetics of BCR-ABL Transcripts in Imatinib Mesylate treated Chronic Phase CML (CPCML), A Predictor of Response and Progression Free Survival
Purpose: To assess the kinetics of molecular response to Imatinib Mesylate (IM) therapy in predicting progression free survival (PFS), sustained hematological, and cytogenetic responses in CPCML. Methods: Ninety five new...