Spectrophotometric Determination of Risedronate in Pharmaceutical Formulations via Complex Formation with Cu (II) Ions: Application to Content Uniformity Testing
Journal Title: International Journal of Biomedical Science (IJBS) - Year 2008, Vol 4, Issue 4
Abstract
A simple, sensitive, rapid and accurate spectrophotometric method was developed for the determination of risedronate, a bisphosphonate drug important for the treatment of a variety of bone diseases, in raw material and pharmaceutical formulations. The proposed method is based on complex formation between risedronate and Cu (II) ions in acetate buffer of pH5.5. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of risedronate in concentration range of 2-40 µg/mL with detection limit of 0.03 µg/mL (9.51 × 10-8 mol/L). The molar absorbtivity was 8.00 × 103 l/mol/cm. The method was successfully applied for the determination of risedronate in tablet dosage form with mean percentage recovery of 101.04 ± 0.32. The results obtained were favorably compared with those obtained by the comparison method. Furthermore, the proposed method was applied for content uniformity testing of risedronate tablets.
Authors and Affiliations
M. I. Walash, M. E. -S. Metwally, M. Eid, R. N. El-Shaheny
Keywords
Related Articles
- EP ID EP82955
- DOI -
- Views 128
- Downloads 0
Regulating Inflammation in the Heart
Cardiovascular disease is the leading cause of death in the United States and estimated to be the leading cause of death worldwide by the year 2020. Many pathogens including bacteria, protozoa, and viruses are associated...
An investigation on the solid dispersions of chlordiazepoxide
The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid...
Suppressive Effects of Intrathecal Application of Diazepam on Visceral Pain and Hyperalgesia Induced by Intracolonic Instillation of Formalin
Using an animal model of colonic inflammation, the effects of intrathecal (i.t.) diazepam (0.02mg/kg, 0.08mg/kg and 0.15mg/kg) on visceral pain-related behaviors and hyperalgesia associated with colonic inflammation were...
Changes in Mice Brain Spontaneous Electrical Activity during Cortical Spreading Depression due to Mobile Phone Radiation
The objective of the present study was to investigate changes in spontaneous EEG activity during cortical spreading depression (CSD) in mice brain. The cortical region of anaesthetized mice were exposed to the electroma...
Retroperitoneal Hemorrhage from Adrenocortical Carcinoma as a Poor Prognostic Factor
In most patients, adrenocortical carcinoma is diagnosed at an advanced stage of the disease. A sudden retroperitoneal hemorrhage may sometimes be the first symptom of the adrenal cancer. We describe four patients with ad...