Spectrophotometric methods for quantitative estimation of sertraline hydrochloride from tablet formulation
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2014, Vol 3, Issue 4
Abstract
Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of Sertraline Hydrochloride from its tablet formulation. The developed methods are based on formation of chloroform extractable colored complex of drug with alizarin red and tropaeolin ooo. The chloroform extracted complex of drug with alizarin red showed absorbance maxima at 425.0 nm and linearity was observed in the concentration range of 20-90 µg/ml (method-I), with tropaeolin ooo showed absorbance maxima at 485.0 nm and linearity was observed in the concentration range of 3-24 µg/ml (method-II). Results of analysis for both the developed methods were validated statistically and by recovery studies.
Authors and Affiliations
Ravindra N
Keywords
Related Articles
- EP ID EP656701
- DOI -
- Views 69
- Downloads 0
Method development and validation for the simultaneous estimation of sitagliptin and metformin in tablet dosage form by RP-HPLC
A RP-HPLC method was developed and validated for the simultaneous estimation of Metformin Hydrochloride (MET) and Sitagliptin (STG) in pure and pharmaceutical dosage form. Chromatography was carried on Phenomex (kromosil...
RP-HPLC Method Development and Validation for the Simultaneous estimation of Simvastatin and Ezetimibe in Tablet Dosage Form
A simple reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous determination of Simvastatin and Ezetimibe in pharmaceutical tablet dosage form. Chromato...
Compatibility and stability studies of levadopa, carbidopa, entacapone and natural bioenhancer mixture
Levodopa, Carbidopa and Entacapone are used for the treatment of Parkinsonism disease. Piperine is an alkaloid from Piper species is reported to enhance the oral bioavailability of co-administered drugs. Piperine can imp...
Formulation, characterization and Evaluation of Transdermal Film Containing Naproxen
Transdermal drug delivery system has numerous advantages over the more traditional drug delivery systems. This includes high bioavailability, steady drug plasma concentration, absence of first pass hepatic metabolism eff...
Synthesis, Characterization and Biological evaluation of substituted Pyrazole derivatives
The work presented in this article consists of synthesis, characterization and biological evaluation of substituted pyrazole derivatives. Pyrazole derivatives have been shown to have wide variety of pharmacological activ...